DIAKARB (Diacarbum). Atsetilamino 2--1 3 - 4 tiadiazol-5- sulfamid.

     C inonimy : Atsetazolamid, Fonurit, Acetazolamide, Acetazolamidum, Acetamox, Anicar, Dehydratin, Dilamox, Diluran, Diuramid, Ederen, Eumicton, Fonurit, Glaucomide, Glauconox, Glaupax, Lediamox, Natrionex, Nephramid, Renamid, Sulfadiurine and others.

     The white crystalline powder. Very little is soluble in water and alcohol, easy-to grizzled.

     Diakarb a representative group of drugs, which are linked to the ability to dominate the electoral activity karboangidrazy (coal angidrazy) - enzyme involved in the hydration and dehydration of coal acid. This property was first detected in streptotsida sulfanilamidnyh and other compounds, but diakarba, which also contains molecules sulfonamidnuyu group expressed significantly stronger.

     Diakarb can be used with care to the various states in which to reduce karboangidrazy activity. It is the largest used as diureticheskogo funds, as well as to treat glaucoma.

     Diuretichesky effect based on oppression karboangidrazy activity in the kidney and change the core of acid (CCO) in the body. It operates mainly in proximal Channel. Oppression karboangidrazy erodes education coal and reduce acid reabsorption and quite epithelial Na + channel; Increased allocation of urine and N + HCO 3-, and therefore significantly increase the allocation of water; Urine pH increases. Under the influence of potassium ions diakarba also available in larger quantities. The increase in allocation chloride is not happening. In connection with increased allocations from the body bicarbonate can develop disorders. Following the reception diakarba alkaline reserve 1 to 2 days back to the original.

     Diakarb effective when administered. It is rapidly absorbed from the gastrointestinal tract and, in the tissues and organs, in oppressing them karboangidrazu.

     As usual diuretika diakarb used relatively infrequently, as there are more effective drugs, but it is especially shown swelling due to cardiopulmonary diseases, if lowering elevated CO and bicarbonate in the blood.

     In connection with the reduction of CO in the blood, diakarb in some cases improves patients emphysema light.

     Expressed diuretichesky effects when combined application diakarba and eufillina.

     Since ammonium chloride and other acidifying diuretikami combine diakarb not be as diuretichesky effect with reduced or even completely disappears.

     With swells of renal origin diakarb ineffectual, and in liver cirrhosis use inadvisable because of the sensitivity of patients to gipokaliemii, and because of the potential for increasing the ammonia content in the blood.

     Diakarb also used in the treatment of glaucoma in various stages of development (in a simple, long, juvenile and other forms of primary and secondary glaucoma). Drug induced lowering inner pressure due to oppression karboangidrazy ciliated body and reducing secretions watery moisture, as well as to improve its flight. Narrowing diakarb maybe it is; It can be used with cataract. The most pronounced anti-hypertensive effect in patients with acute glaucoma attack.

     Diakarb designate also epilepsy; Therapeutic effect might be related to the oppression karboangidrazy brain activity; It should be noted that under the influence diakarba decreases the spinal fluid. Diakarb particularly effective in patients with rare absansami.

     Is diakarb inside. Under the dose of 0,125 - 0.25 grams (less than 0.5 grams). Is a diuretic 1 times a day every day or every other day courses on Feb. 4-day interval few days. With frequent use diuretichesky effect decreases as the content of bicarbonate in the blood falls heavily; For these intervals quite content increases again and again reception diakarba increases for sodium ions and alkaline with urine, as well as increased diureza. Higher doses did not increase the effect.

     When glaucoma diakarb appoint 0,125 - 0.25 g reception from 1 to 3 times a day, sometimes two times a day (morning and evening) a day. Once every five days admission diakarba make a break for two days. Good effects, in some cases, while appointing diakarba and mioticheskih funds. Length of diakarba with glaucoma depends on the nature of the disease and treatment.

     In preparation for the operation (about glaucoma) to provide 0.5 grams a day before the operation and the morning of the operation.

     In epilepsy usually designated for 0.25 - 0.5 grams per day.

     Patients with rare absansami (see Trimetin) added diakarb by 7 - 10 days after the start of treatment for 0,125 - 0,25 g per night. The agent gave to 3 days with a break every fourth day.

     Diakarb malotoksichen and usually well patients even in long-term use, but some patients may be asleep, violation guidance, parestezii; These phenomena may be linked to the oppression karboangidrazy and gipokaliemiey. As the dose or eliminate drug side effects quickly pass.

     With a long reception diakarba to maintain a balance of electrolytes in the body should be sodium bicarbonate.

     Because of that older people with the provision of potassium in urine by diakarba increases more than the young people in geriatric practice limited to 1 - 2-day course with a mandatory correction potash exchange.

     Contraindications : prone to disorders, increased allocation of sodium and potassium ions, Edison disease, acute liver disease and kidney failure, diabetes and Uremia. There should be appointed diakarb in the first three months of pregnancy.

     Method of issuance : powder; Pills to 0.25 grams in a package of 24 pieces.

     Storage : in a dry place.

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