DIAZOKSID (Diazoxide).

     Hlor-3- 7-methyl-2 H-1, 2,4-benzotiadiazin-1, 1-dioxide.

     Synonym : Giperstat, Hyperstat.

     On chemical structure has similarities with tiazidnymi diuretikami (see Gidrohlortiazid), but no action has diureticheskogo and has antihypertensive activity expands arterioly and reduces peripheral vascular resistance.

     Considered as one of the main peripheral vazodilatatorov. Mechanism of poorly understood.

     A intravenously to quickly reduce blood pressure in malignant hypertension associated with kidney disease, and with PNDS crises. Hypertension develops through a 1 min after, reaches through 2-5 minutes and lasts until 2-12 h.

     Dose for adults and adolescents is 1-3 mg / kg (150 mg). If necessary, re-establish (through 5-15 minutes) to achieve the desired effect. In the future, if necessary, to give space for 4-24 h. Usually imposed during 4-5 days, and go on to receive antigipertenzivnyh drugs inside.

     Children are also introducing dose of 1-3 mg / kg (or at the rate of 30-90 mg per m2 of body surface 1).

     In applying diazoksida could experience a delay of sodium in the body with the development of oedema, hyperglycemia, thirst, sleepiness, tachycardia.

     The drug should not be brought under the skin and intramuscularly because of the tissue irritation.

     Product : 1.5% injection of ampoules and 20 ml (0.3 g).

     Storage : at a temperature no higher than 10 ° C in the dark spot. May not be frozen.

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