DIDANOZIN (Didanosine).

     2? 3? - Didezoksinozin.

     Synonym : Videx, Videx.

     The white crystalline powder. Mg in the water. Frailties in an acid environment.

     The structure and actions similar to other nukleozidnym antiretroviral drugs. In cell organism into didezoksiadenozin -5? - Trifosfat, overwhelming VICH-1 reverse transcriptase activity.

     When ingestion bioavailability of approximately 30%, with max-0,5-1 h, T? 0,8-2,7-h; display kidneys.

     Applied mostly with HIV.

     Assign inwards in the form of tablets or powder for 30 minutes before eating. Razzhevyvayut pills, or carefully chop manually, or disperses in? glasses of water. Powder to throw in 1 cup of water.

     Adults weighing more than 60 kg designate tablets of 0.2 g or as a powder to 0.25 g 2 times a day (at intervals of 12 h), birth weight less than 60 kg to 0.12 g or 0.167 g respectively to two times a day; children - at the rate of 0.12 g / m 2 per day.

     Possible side effects : diarrhoeal phenomenon Depigmentation retina, peripheral neuropathy, giperurikemiya, hyperglycemia, disruption of the liver and pancreas, blood oppression, allergic reactions, etc.

     Contraindications with pancreatitis, gout, kidney failure, liver cancer, high blood pressure, heart failure, gipertriglitseridemii, pregnancy and breastfeeding.

     Method of issuance : razzhevyvaniya tablets or solution (suspension) for admission to the interior of 0,025; 0.05; 0.1 and 0.15 g (N. 60); Powder for Solution for admission into bags to 0.1; 0.167; 0.25 and 0.375 g, and in vials of 2 and 4 years

     Storage : List B.

Materials allowed to copy only with the active hyperlink to the handbook of medicines