DINATRIEVAYA SOL ETILENDIAMINTETRAUKSUSNOY ACID (Dinatrii aethylendiamintetraacetas).

      Synonyms : Trilon B EDTU, Calsol, Dinatriumedetat, Endrate, Irgalon, Kalex, Prochelate, Questrex, Sequestrene, Sequestrol, Sodium edetate, Tetracemindinatriumi, Titriplex, Trilon B Tyclarosol, Versene and others.

      The white crystalline powder, soluble in water, virtually insoluble in alcohol and ether.

      Dinatrievaya EDTU salt (Na 2 EDTU) applies, as well as calcium and tetatsin- pentatsin, the group kompleksonov.

      Able to form complex compounds with various cations, including calcium ions. This makes it possible to apply EDTU of diseases involving excessive deposits of calcium salts in the body, and pathological skeletal ossification, arthritis with salt deposition, deposition of calcium in the muscle, kidney, the walls of veins, sclerodermia and others sometimes used to treat certain forms Cumulative departments, especially arising from an overdose of cardiac glycosides.

      When used in the treatment must be understood that the therapeutic effects without the side effects are the slow introduction of the drug in the current blood; In these circumstances, interaction with serum calcium is slow and serum calcium did not significantly lowered, as losses reimbursed through the mobilization of calcium fabrics, particularly from bone, and the excess deposits in the organs. With the rapid introduction of a drug physiological mechanisms fail to address lowering serum calcium and can develop severe Tetany.

      EDTU, at the ability to link calcium ions, used as an anticoagulant in blood preservation.

      The major indication for use with the disease are EDTU phenomena calcification : dermatomiozity, sclerodermia, ossifitsiruyuschy myofasciitis.

      For therapeutic purposes using EDTU intravenous drip solution. Let's 5% solution EDTU in isotonic sodium chloride solution, or 5% glucose solution.

      Enter a speed of 8 to 12 drops per minute. Adults and children over the age of 10 to enter and 10 ml 5% solution EDTU, divorced in 200 ml of solvent; Children up to 10 years old, 5 ml of 5% solution EDTU, divorced in 100 mL solvent.

      The course of treatment consists of 15 injection : introducing cycles for 5 days a week from 7-day intervals (all three cycles in the course). Repeat treatment courses through 4-6 months.

      During treatment should monitor the content of calcium and phosphorus in the blood and urine daily. Diet during treatment should lower the number of calcium.

      In preparation for the introduction of non - sometimes there is a burning, which can spread all over the body and kept within 1 to 2 h after injection.

      With the rapid introduction Tetany can develop; In these cases it is necessary to stop the introduction of the drug.

      EDTU not suitable for hemophilia, low blood coagulability gipokaltsiemii, kidney and liver diseases.

      Product : 5% solution in ampoules for 5 or 10 ml (n Solutio Dinatrii thylendiamintetraacetatis 5% of injectionibus p r) in a package of 10 vials.

      Storage : List B. In the dark spot.

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