DINOPROST (Dinoprost) *. 7-[3, 5-Dioksi-2- (3 - 1-oxides oktenil) - tsiklopentil] -5 - geptenovaya acid.

     Dinoprost drug is a form of a prostaglandin F 2.

     Synonyms : PG F2a, Enzaprost, Amoglandin, Enzaprost-F, Minprostin F2a, Panacelan F Prostaglan, Prostarmon, Prostarmon F, Prostin F2a.

     Dinoprost, Trometamol (Prostaglandin F 2 a Trometamol) contains prostaglandin F 2 in a set of 2-amino (oksimetil) - propane-1, 3-diolom (1:1). In one activity, 3 µ g of the drug with 1 µ g dinoprosta (acid).

     Dinoprost is the main representative group prostaglandines used in obstetric practice. Has expressed catalytic effect on the smooth musculature uterus.

     Assign to initiate and stimulate contractile uterine activity in the different periods of pregnancy, and to cause an abortion.

     The drug has a direct stimulus to the specific functional structure of cells Oxytocics.

     Initiation of contractile uterine activity occurs (unlike the effect of the application of oxytocin, please) at any time of pregnancy, and the effect is independent of the degree of disclosure of the cervix.

     For abortion PG F 2 apply for a medical condition, primarily in the later stage of pregnancy (from 13rd on the 25 th week).

     The principal means of prostaglandines are intravenous, ekstraamnialny, intraamnialny; They also impose intravaginalno. The method of choice and dose, depending on the evidence and endurance. For abortion up to 15 weeks time to ekstraamnialnoe introduction, and after 15 weeks-intraamnialnoe.

     For intraamnialnogo of PG F 2 a recommended dose of 40 mg once, giving better results than a 25 mg 2 times every 6 hours Action 40 mg PG F 2 corresponds to a 2, 5 mg of synthetic analogue - 15-methyl-2, a PG F. When using a ekstraamnialnom PG F 2 for a 250-1000 mg every 1 to 2 hours

     To initiate a generic type of PG F 2 a intravenously. In 500 ml of 5% glucose solution and isotonic solution of sodium chloride to throw 5 mg product and introduce drip, starting with 10 to 15 drops per minute, and then every 10 to 20 minutes increases the number drops to 4 - 5 until the regular labor. The maximum dose should not exceed 25 µ g / min (40 drops per minute).

     PG applied to a intravaginalno F 2 (5 mg every 2 h).

     To designate rodovozbuzhdeniya sometimes prostaglandin F2a with oxytocin.

     While the application of prostaglandin F 2 in the form of a tablet input intratservikalno (17, 5 mg) for the expansion of channel cervix.

     Application prostaglandines only in specialized hospitals. For best effect should be carefully selected and the method of dose. Please note that admission prostaglandines various possible side effects. Prostaglandin may cause nausea, vomiting, diarrhea, tachycardia, bronhiolspazm with intravenous non-local irritation (flebity), increased body temperature. With extra intraamnialnom and introduction of the above doses are expressed less side effects.

     Drugs prostaglandines for pregnant with scars on the uterus, while Gray and clinically narrow pelvis, women with severe cardiovascular disease, kidney disease, liver, blood system, with a propensity to bronhiolspazmu, glaucoma (in a possible rise in inner pressure).

     Optimal dose and ways of prostaglandines and their synthetic analogues continue to be refined.

     In Hungary, a prostaglandin F 2 is entitled "Enzaprost F" (in capsules of 1 and 5 mg).

     Along with prostaglandinom PG F 2 used as a synthetic derivative of 15 - Methyl-2, a PG F providing a stronger and more a long operation. In 2 dose, 15 mg 5-methyl-PG F2a acts like 40 mg PG F. Methyl PG-15 F 2 is a known abroad <Methyldinoprost>. The drug used in solution and candles.

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