DIFENIN (Dipheninum).

     A mixture of 5, 5 and difenilgidantoina gidrokarbonata sodium (in the ratio of 85:15).

     Synonyms difenilgidantoina and its sodium salt : Alepsin, Dihydantoin, Dilantin sodium, Diphedan, Diphentoin, Epanutin, Eptoin, Hydantal, Hydantoinal, Phenhydon, Phenytoinum, Sodanton, Solantoin, Solantyl, Zentropil and others.

     The white crystalline powder. Almost nerastvorim water; Dilute solutions of 1% caustic alkalis.

     Available in the form of tablets containing 0,117 grams and 0,032 grams difenina gidrokarbonata sodium. These tablets with difenilgidantoina of sodium.

     Difenin derives gidantoina close to the chemical structure of barbiturovoy acid. Has protivosudorozhnoe act without express relief effect.

     When ingestion absorbed at different rates. Peak concentrations in plasma through a 3-12 hours After blowing quickly spread around organs and tissues, including brain tissue. Very associated plasma protein. Less than 5% is allocated to the urine unchanged, the remainder are metabolised liver enzymes. The main metabolite (product paraoksifenila) idle, out with bile and urine as glucuronide.

     Difenin used to treat epilepsy primarily with large fits of convulsions.

     Assign inside. To prevent gastric mucosal irritation (because of the alkaline reaction) take during or after eating.

     Adults usually 1 / 2 to 1 tablet 2-3 times a day. If necessary, add to the daily dose of 3-4 tablets.

     Higher doses for adults : single 3 tablets daily 8 tablets.

     Children under 5 years are to 1 / 4 tablet difenina 2 times daily, 5 to 8 years and 1 / 4 tablets 3-4 times a day over 8 1 / 2 - 2 1 pill twice a day.

     In inefficiency difenina simultaneously appoint phenobarbital or other protivoepileptichesky product.

     Difenin effective in some forms of cardiac arrhythmias, especially in infants caused by overdoses of heart glyukozitov (see Antiaritmicheskie drugs)

     Due to the overwhelming effect on the vestibular reflexes difenin may have a beneficial effect in some forms of the syndrome Menera.

     When treating difeninom possible side yavleniyan : dizziness, arousal, increased body temperature, difficulty in breathing, nausea, vomiting, tremor, ataxy, eye, allergic reactions (skin rashes, itching of the skin, etc.), lymphadenopathy, and other phenomena girsutizma relatively often develops hyperplasia gums.

     When expressed adverse events should gradually reduce the dose or stop the use of drugs.

     Drugs and its derivatives, levomitsetin, cumarins, acetylsalicylic acid, teturam dismal biotransformation difenina and can enhance its effects. Instead, phenobarbital, carbamazepine accelerates the metabolism.

     Difenin zabolevannyah contraindications to liver, kidney, heart failure, cachexia.

     If pregnancy should be avoided difenina destination.

     Product : tablets in a package of 20 pieces.

     Storage : List B. The well ukuporennoy packaging, in the dark place.

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