DIPIROKSIM (Dipiroximum). 1 1'- Trimetilen- bis - (4-oksiminometilpiridiny bromide) Monohydrate, or 1 1'- trimetilen- bis - (4-piridiniy- aldoksim) dibromide.

     Synonyms : Trimedoxime bromide, Trimedoximi bromidum, TMV 4.

     Light yellow, powder melkokristallichesky odourless, bitter taste. The easily soluble in water, dry in alcohol. Aqueous solutions (with the addition of a buffer), pale yellow; PH 3, 7, 4, 2; Sterile with 100 'C for 30 min.

     Reaktivator cholinesterase. Applied in combination with drugs holinoliticheskimi (atropine, aprofen, etc.) with organophosphorus compounds poisoning.

     Depending on the severity of poisoning using dipiroksim once or several times.

     In early signs of poisoning (vozbuzhenie, cramps, sweating, slyunootdelenie, primary phenomenon bronhorei) entering into the skin 2 to 3 ml of 0.1% solution of atropine sulfate and 1 ml 15% solution dipiroksima. If poisoning symptoms do not disappear, the second drive and dipiroksim atropine in the same dose (of 1 to 2 mL of 15% solution dipiroksima).

     In a Heavy events (fibrillyarnye car muscles, convulsions, coma or soporoznoe, heavy bronhoreya) impose up to 3 ml of 0.1% solution of atropine sulfate intravenously and intramuscularly at the same time (and, in severe cases, intravenous) 1 ml 15% solution dipiroksima. Introduction of the dose of atropine in repeated every 5 to 6 minutes to complete and edema brohorei signs of atropinizatsii. Dipiroksim imposed if necessary through 1 - 2 hour again. The average dose dipiroksima in severe cases, 3 to 4 ml of 15% solution (0,45 - 0,6 g). In the most severe cases, involving stops breathing, to be 7 - 10 ml dipiroksima.

     For patients who are unconscious, and with the difficulty intravenous drugs can be introduced vnutriyazychno. Enter a therapeutic dose.

     Dipiroksim in combination with atropine shown to apply only if there were clear signs of poisoning, but if not, when it is known that a lethal effect on the organism (oseltamivir).

     The literature is an indication that dipiroksim (in combination with atropine) is effective in the treatment of gastric ulcers and duodenal ulcers. Dipiroksim suppresses the secretion of gastric juice and hydrochloric acid.

     There is also evidence of the application for dipiroksima edema paroksizmalnyh heart rhythm irregularities : the introduction of non struyno 150 mg (1 ml 15% solution in 10 ml isotonic sodium chloride solution), followed by intravenous drip a 2 ml 15% solution (300 mg) in 100 ml isotonic solution of sodium chloride (total 450 mg). The rationale for the use of an observation of oppression with coronary heart disease and heart attacks activity of tissue and plasma cholinesterase.

     Method of issuance : powder; 15% solution of 1 ml ampoules in a package of 10 vials.

     Storage : List B. In a dry, cool, the dark spot.

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