DIPLATSIN (Diplacinum). 1, 3 - Bis (~ - platinetsiniy- etoksi) - benzene dichloride.

     Synonyms : Diplatsina dichloride, Diplacini dichloridum.

     The white crystalline powder. Very easily soluble in water. The solutions (pH 4, 5, 7, 2) sterile when 100 C for 30 minutes.

     Antidepolyarizuyuschy muscle. As the operation is similar to d-tubokurarinom.

     Introduction diplatsina the body by kurarepodobnym reality arises, in terms of temporary nerve conduction and muscle relaxation skeletal muscles. By introducing small doses dipla Qing may occur skeletal muscle relaxation without stopping breathing. Reducing breathing with a high dose due to shut down operation of the respiratory muscles; With artificial breathing medication moved to the relatively high doses without oppression bloodstream. Paralysing effect on nerve conduction muscle removed anticholinesterase substances.

     The sequence of muscle relaxation is the same as when applying d tubokurarina.

     Applied diplatsin to facilitate tracheal intubations with endotrahealnom anaesthesia and to better relax muscles, together with operational shatelstvah in narcosis with artificial ventilation of the lungs.

     For tracheal intubations injected (slowly, over 2 3 min), 100-200 mg diplatsina (5 to 10 mL of 2% solution), an average of 1 5 2 1 mg per kg of body weight. After 1 to 2 minutes after the relaxation of muscles and open the window give voice box intubatsionnuyu tube. Since the introduction diplatsina necessarily be artificial ventilation light : first, using masks, and after tracheal intubations through intubatsi little tube.

     The relaxation of muscles after the initial dose diplatsina continue is about 1 hour. If necessary, longer relaxation impose de platsin again in half of the initial dose. Total dose for the duration of the operation can reach 300 to 400 mg (15 to 20 mL of 2% solution). When air anaesthesia to reduce the dose of 1 / 3.

     For a complete shutdown independent breathing impose diplatsin dose of less than 200 mg in one day when the patient body weight 60 to 70 kg.

     Recently diplatsin have successfully applied for immobilizing eyeballs in oftalmohirurgii. The reason for this is that diplatsin (and other muscle) retrobulbarnom with a neuro-muscular blocking traffic on the external eye muscles, thereby reducing pressure on the eye muscles ekstraokulyarnyh apple and causing his akineziyu. Diplatsin this to be in operation (in local spending aneste) retrobulbarno.

     This 1 ml diplatsina 2% solution (20 mg) to throw 9 ml 2% races creators novocaine, then received 1 mL of solution (2 mg) mixed in 4 ml syringe with 2% solution of novocaine and enter transkutanno in orbital space.

     If necessary relaxation of a direct muscle to impose directly on the course of the muscle 0.1 mg diplatsina 2% solution (2 mg).

     Diplatsin well tolerated and no significant adverse phenomenon lines. It has less effect ganglioblokiruyuschee than d-tubokurarin, is the release of histamine, it is laringo- and bronhiolospazma. With the introduction of large doses can diplatsina slight figures for AD (15 - 20 mm Hg. Art.) .

     It must, however, keep in mind that the use diplatsina (and other kurarepodobnyh muscle) is available only in indotrahealnom anaesthesia and all the conditions for the tank and that intubatsi little tube removed only after the full restoration of self-breathing.

     Residual Effects diplatsina blocks away thinking of prose or other anticholinesterase drugs (in combination with atropine) after the restoration of self-breathing movements.

     Diplatsin, like other muscle, is not suitable for miaste of; Caution should be applied in patients with pronounced violations agreements liver and kidney functions and at the oldest ages.

     Product : 2% solution of 5 ml ampoules in a package of 10 vials.

     Storage : List A. In the dark spot.

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