DITRAZINA TSITRAT (Ditrazini citras). 1-Metil-4- dietilkarbamoilpiperazina citrate.

     Synonyms : Loksuran, Banocide, Carbamazine, Carbilazine, Caricid, Citrazan, Decazine, Diaethylcarbamazini citras, Ditrazinum citricum, Filabran, Hetrazan, Notezine, Supatonin, Unicarbazan and others.

     The white crystalline powder. Very easily soluble in water, it is difficult to alcohol.

     Ditrazin is widely used to treat filyariatozov (vuhererioz, brugioz, onchocerciasis, akantoheylenematoz). There also ascariasis, but less effective than piperazine and its salts, and more toxic.

     Assign with filyariatozah inside, the rate of 2 mg / kg 3 times daily for 10 days. The daily dose should not exceed 0.4 g. Depending on the portability and efficiency of a 3 to 5 courses (and an 10 - 12 days). Performance determine the loss of blood and mikrofilyary klinichesnih proyavleiy disease (plasma in the skin, gipereozinofiliya etc.).

     When applying for the frequency of drug side effects : skin itch, the emergence or strengthening of skin deterioration and, less frequently, cough, Eosinophil infiltrates, lymphadenopathy, sometimes increasing the size of the liver and spleen, etc. If onchocerciasis may exacerbate inflammation of the eyes (clouded vitreous body relaxation or blindness). Therefore, in preparation onchocerciasis, accompanying destruction eye Wednesday, contraindications.

     In stark expressed side events medication temporarily cancel, hold desensibiliziruyuschuyu therapy.

     Nor should appoint ditrazinom with steroid drugs, as well as oppression lymphoblastic tissue can increase activity parasites.

     Method of issuance : powder, pill to 0.05 and 0.1 g in a package of 30 and 50 pieces.

     Storage : List B. The well ukuporennoy packaging.

Materials allowed to copy only with the active hyperlink to the handbook of medicines