EMBIHIN (Embichinum).

     Methyl bis - (b-chloroethyl) - amine hydrochloride.

     Synonyms: Mustargen, Caryolysine, Chlorethazine, Chlormethine, Dichloren, Dimitan, Duamin, Erasin HN2, Mechlorethamine hydrochloride, Metichloramine, Mustargen, Mustine, Nitrogranulogen, N-Yperit, Stickstoflost and others.

     The white crystalline powder, soluble in water. Solutions (in isotonic sodium chloride solution) to prepare (because of their weak) ex tempore.

     The product is active in chronic mieloze, limfo- and retikulosarkome, chlamydia, mushroom avium, melkokletochnom cancer light.

     Currently it is mainly used in the treatment of infection in the complex therapy.

     Enter embihin intravenously. When <shock> how to enter during the four days in total dose of 0.4 mg / kg (at 0.1 mg / kg per day) or 0.4 mg / kg once. Sometimes enjoyed <drobnoprotyazhnoy> methodology: introducing drug dose 5 - 6 mg 3 times a week; Total dose (8-20 introductions) is 40-120 mg.

     Treatment with the lower end of white blood until 2 5 3 x 10 9 / L.

     Embihin can be entered in seroznye cavity (0.2-mg / kg at 10-50 ml isotonic sodium chloride solution) if they effusion containing tumor cells.

     Treatment embihinom should be under careful medical supervision. Using drugs can be complications and side effects associated with its local irritating properties and the general toxicity dsystviem, especially the influence of disorders.

     With the introduction of intravenous embihina should be monitored closely to ensure that the solution does not come under the skin as possible emergence of infiltration and necrosis of tissue. In the case of solution into the subcutaneous fat in the skin should be immediately put in place a number of isotonic sodium chloride solution. If infiltration apply compresses.

     It should guard against falling product solutions for light skin and skin patients and medical staff. If this happens, it is necessary to thoroughly wash off immediately product water.

     To prevent development in patients flebita (especially when multiple introductions), it is after injection into the vein additional 20 ml of warm solution Ringera and not starve veins from the field after giving injections.

     Part of patients through the 1 to 3 h after the drug are nausea and headache, sometimes vomiting. To reduce or eliminate vomiting appoint aminazin (0,025 grams inside or intramuscularly after 1 h after injection embihina) or etaperazin. You can also enter embihin evening (after dinner), and appoint sleeping at night.

     In the treatment embihinom need to monitor developments picture blood. Serious complications with the drug overdose can be profound depression as bone marrow suppression with a sharp gemopoeza until phenomena aplazii tissue disorders (fatal).

     When treating fractional doses embihina impact on leyko- and trombopitopoez expressed less.

     Storage: List A.

     Note.

     With embihinom and all other cytotoxic drugs must be taken, except for pitching products and solutions to the skin and mucous lining in the stomach.

Materials allowed to copy only with the active hyperlink to the handbook of medicines