ENALAPRIL (Enalapril) *. 1-[N-[S] -1 - Karboksi-3- fenilpropil] -L- alanil] -L- proline-1 'ethyl ether.

     Synonyms: Renitek (name drug company RCK ME & SO. , INC. , Rahway, N. J., U. S. A.), Enap, Dynef, Enap, Enapren, Enaprin, Lotrial, Noprilene, Renital, Renitec, Reniten, Vasotec, Xanef etc.

     Issued in the form maleata.

     Like Captopril is an enzyme inhibitor, angiotensin konvertiruyuschego. According to the chemical structure similar to Captopril, but is more complex, moreover, does not apply to sulfgidrilnym compounds (no groups in the molecule SH).

     Amlodipine is prolekarstvom "; In the body it hydrolyses enalaprilata education, which itself is the enzyme inhibitor.

     When you receive inside amlodipine rapidly absorbed and the long-term effect.

     Indications for use are the same as for Captopril: various forms of hypertension, renovaskulyarnaya hypertension, cardiac failure long.

     Can apply for monotherapy and in combination with other means antigipertenzivnymi (diuretikami etc.).

     Assign inside amlodipine (regardless of when meals).

     When treating hypertensive bolezni6 initial dose is 10 to 20 mg per day (once). Further dose picked individually for each patient, usually 20 mg once a day. Daily dose should not exceed 40 mg. In nerezko expressed hypertension enough to nominate 10 mg per day.

     In renovaskulyarnoy appoint hypertension drug in smaller doses (due to the higher sensitivity to inhibition angiotenzinkonvertiruyuschego enzyme). Initial dose is usually 5 mg per day. Then dose picked individually. Daily dose should not exceed 20 mg (once daily).

     In heart failure appointed from 2, 5 mg, and then gradually increase the dose to 10-20 mg (one-two receiving).

     In all cases, excessive decrease AD lower dose.

     When using amlodipine possible dizziness, headaches, ortostaticheskaya hypotension, nausea, diarrhoea, cough, muscle cramps, in rare cases, violation of kidney function, neutropenia. Possible allergic reactions (skin, etc.) and, in some cases, development angionevroticheskogo oedema.

     Amlodipine contraindications to the high degree of sensitivity to angiotensin konvertiruyuschego enzyme inhibitors in pregnancy. Amlodipine and enalaprilat are some numbers with the women's milk, which should be careful in appointing a drug nursing mothers. Children amlodipine not appointed.

     For patients with renal insufficiency may be necessary to reduce the dose and frequency of receiving the drug.

     Form release: pills to 0,005; 0.01 and 0.02 g (5; 10; 20 mg).

     Storage: List B. In a dry, sheltered from the world scene.

Materials allowed to copy only with the active hyperlink to the handbook of medicines