ESTRATSIT (Estracyt).

     Estradiol 3-[bis (2-chloroethyl) karbamat] 17 - (dioksifosfat).

     Synonyms: Emcyt, Estramustine phosphate and others.

     According to the chemical structure is a combination of phosphoric ester estradiola balance bis - (b-chloroethyl) - amine (see Embihin).

     Is estrogen and tsitotoksicheskim funds, effective with prostate gland cancer. Has antigonadotropnymi properties. In normal dosage is strong oppression blood.

     Apply for prostate gland cancer in stage neglected and inefficiency hormone therapy.

     Assign inside and intravenously. Inside are for 1 hour before eating or two hours after eating for 2 to 3 capsules (280 mg in a capsule) two times a day. ?high water. At the same time, there should be no milk, dairy products or products that contain calcium.

     If no effect within 3 - 4 weeks of treatment ceased.

     You can start treatment with intravenous injection of 0.3 g (300 mg) daily for 3 weeks, followed by reception 2 to 3 capsules two times a day or in a vein of 0.3 g 2 times a week.

     Enter in the veins to be slow during the 3 to 5 minutes (to avoid flebita).

     You can enter solution estratsita a limited (no more than 3 hours). To dissolve the contents of the ampoule in 8 mL solvent vstryahivaya slightly, but no Solutions, then razvodyat in 250 ml of 5% glucose solution. Applications for this purpose isotonic sodium chloride solution is not allowed.

     After intravenous estratsita should enter (not removing the needles), a small amount of 5% glucose solution (to wash needles).

     In applying estratsita potential for nausea, vomiting, diarrhoea, hemorrhagic, in rare cases, allergic reactions, more than in the heart. There venous, Gynecomastia.

     The product contraindications with acute liver disease and heart physiotherapists.

     Method of issuance: capsules of 0.28 g (280 mg) in vials for 100 capsules; 1, 5% solution in 10 ml ampoule (150 mg vials), and 3% solution in 10 ml ampoule (300 mg vials) in the package of 10 vials to annex 10 vials solvent.

     Storage: at a temperature of not more than + 25 C.

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