ETIONAMID (Ethionamidum).

     Tioamid a-etilizonikotinovoy acid, or 2-etil-4- tiokarbamoil-4- Pyridine.

     Synonyms: Tionid, Trekator, Amidazin, Athioniamid, Ethionamide, Ethioniamide, Etionizina, Iridozin, TN 1314, Nizotin, Rigenicid, Thianid, Thionid, Trecator, Trescatyl and others.

     Ethionamide is tioamidom izonikotinovoy acid. According to the structure and antibacterial properties similar to isoniazid, but less active, however, operates on the strains resistant to isoniazid power.

     Previously seen as anti-TB drug II series. There are currently more widely applied its analogue Prothionamide (see).

     Assign inside and candlelight. Adults are on the inside of 0.25 g three times a day; While good for portability - 0.25 g 4 times a day; When poor portability, patients over 60 years of age and body weight less than 50 kg to 0.25 g 2 times a day.

     The product is taken after the meal.

     Daily dose for children at the rate of 0,01 - 0,02 g / kg, but not more than 0.75 grams per day.

     Ethionamide can be combined with the anti-tuberculosis drugs if they retained sensitivity testing, as well as with tsikloserinom or pyrazinamide.

     Ethionamide also used to treat leprosy.

     When you receive etionamida might diarrhoeic disorders: the deterioration of appetite, nausea, vomiting, flatulence, abdominal pain, liquid stools, loss of body mass. There are also plasma-type rash on the skin or eksfoliativnogo dermatitis. Occasionally there insomnia, depression.

     To avoid side effects of nicotinamide designate 0.1 g 2 - 3 times a day.

     You can also use pyridoxine (1 - 2 mL of 5% solution) intramuscularly. Patients with low acidity in the digestive juice admission etionamida should take hloristovodorodnuyu acid (salt), divorced or zheludochyy juice, and in high acidity - Antacids funds.

     Ethionamide must designate with caution when zheludochnokishechnogo tract infections and liver.

     Form release: tablets covered with skin, on 0.25 g in the package of 50 pieces.

     Storage: List B. In a dry, sheltered from the world scene with a temperature higher than + 20 C.

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