ETRETINAT (Etretinate).

     Ethyl ether 9 - (4-metoksi-2, 3, 6-trimetilfenil) -3, 7-dimetil2, 4, 6, 8-nonatetraenovoy acid.

     Synonyms: Tigazon, Tigason, Tegison, Tigasan, Tigason.

     According to the chemical structure similar and retinol, is a synthetic derivative retinoevoy aromatic acids (retinoidom).

     Synthesis etretinata and other derivatives retinoevoy acid (izotretiona etc.) taken in connection with the clinical effectiveness of retinol (vitamin A) in a number of skin diseases (see Retinol).

     It turned out that etretinat (tigazon) provides therapeutic effect on blood, ihtioze, disease Dare, diskoidnoy red lupus and certain other dermatological diseases.

     The product in the form of capsules appointed interior. The dose for adults is generally pleased with the 30 mg per day (three capsules of 10 mg); Take time ?high food or milk. After 2 to 4 weeks of treatment in the case of portability can be a good Larger doses up to 75 mg / day (3 capsules of 25 mg). Supporting dose was then 30 mg per day. Usually treatment continues 6 to 8 weeks. In return for repeat treatments.

     For treatment of other diseases appoint 10 to 30 mg per day.

     The product has a curative effect, but relatively often causes side effects.

     Possible side effects (skin itching, drought oral mucous membranes, deskvamatozny Heilit, hair loss, high concentrations of lipids in the blood, tissue calcification, ossification, etc.) requires careful monitoring of patients, individual dosage.

     A serious side effect is tigazona its teratogenic effect. Therefore, it can not appoint women not only during pregnancy but also throughout the childbearing age.

     Tigazon not apply to liver and renal failure (80% etretinata allocated in the form of metabolites with bile, 20% of urine). Report the drug from the body slowly; Possible cumulative phenomenon.

     Due to the high risk of hepatitis B should not be used concurrently with etretinat metotreksatom.

     Given the possibility of severe side effects, should be very careful to appoint tigazon children (only under special conditions). The dose 0.5 mg per 1 kg of body weight per day. Supporting dose-0.1 mg / kg / day or every other day.

     Form release: capsules, containing 0.01 or 0,025 grams (10 or 25 mg) etretinata.

     Tigazon (etretinat) continue to assign cases to other medicines ineffective, but for side events use remains limited. A search for other similar drugs. One of the new drugs is a fair number atsitretin (A citretin, tretin E).

     According to the structure atsitretin close to etretinatu. Is a etretinatu acid, is a final link in the side chain groups instead S00 S00 S N group N. As of atsitretin also close to etretinatu (tigazonu), but differed on the pharmacokinetic parameters derived from the body faster. Several more moved, but is the same side effects. Like etretinatu atsitretin has teratogenic effects, and may not be appointed to women of child-bearing age (particularly pregnant).

     Preparation is under further investigation.

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