FELODIPIN (Felodipine).

     (±) Etilovy, methyl esters of 4 - (2,3 - dihlorfenil) -1,4 - digidro-2, 6 - dimethyl-3, 5-piridinkarbonovoy acid.

     Synonym: Plendil, Plendil.

     Light yellow crystalline powder. Nerastvorim water well soluble in ethanol and dichloromethane.

     Features of nifedipina, nikardipina and nitrendipina content with fenilnom kernel instead nitrogruppy two chlorine atoms.

     Refers to the calcium channel blockers are long-term (up to 24 h). It affects the conductive system of the heart.

     Completely absorbed in the digestive although bioavailability does not exceed 20% (due to the effects of the first pass through the liver), C max is 2,5-5 h, T? - 11-16 h; output mainly kidneys.

     Apply with arterial hypertension and stenocardia voltage, as well as disease Reynaud.

     Assign to 0,005 grams (5 mg) once a day (morning). If necessary, increase the dose to 0.01 g.

     Side effects and contraindications basically the same as the nifedipina (including his retardnoy forms).

     Form release: retard tablets to 0.0025; 0.005 and 0.01 g (2,5; 5 and 10 mg N) (30, 100).

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