FENDILIN (Fendiline).

     N - (2-phenyl ethyl Benzgidril- etil-N-1-) - amine hydrochloride.

     Synonyms: Senzit, Phenaxazan, Phendilin, Phenoxan, Sensit.

     White or slightly rosy crystalline powder. Few soluble in water. Soluble in alcohol.

     According to the chemical structure similar to a direct prior vypuskavshemusya drug difril (prenilamin, korontin, falikor).

     Both drugs are derived fenilalkilamina and similar in structure to fenaminu.

     Difril (prenilamin), one of the first products that have found the ability to block the passage of cells Sa '~. It was synthesized by the "set" fenilalkilaminnoy molecule substances adrenergicheskie blocking receptors and providing antiadrenergicheskoe effect. It turned out that prenilamin (difril) unlike fenamina no peripheral adrenomimeticheskoy activity is not stimulating effect on the nervous, but repressing the transfer sympathetic impulses promotes coronary vessels, improve blood circulation and metabolic processes in the heart. The product is used as antianginalnogo funds. It was then found its impact on the flow of Sa ~ +, and it was seen as antagonist of calcium ions.

     Recently, due to a lack of selectivity and relatively weak antianginalnoy difril activity was deleted from the range of medicines.

     However, it continued to apply the proposed future product fendilin (senzit), close to prepilaminu.

     But fendilin (senzit) has a moderate effect antianginalnoe with light and mild coronary insufficiency has antiaritmicheskoy moderate activity. Overall, the drug less effective than other drugs in this group.

     Assign inside of 1 - 2 tablets (50 mg) three times a day (most patients on Z00 mg / day).

     Possible side effects: gastric mucosa irritation, pain, nausea, etc., headache, anxiety, allergic reactions.

     Contraindications: pregnancy, the acute phase of myocardial heart attack. Prudence required to defeat the liver. It should appoint a drug with b-adrenoblokatorami.

     Form release: tablets, coated skin (Bean), to 0.05 g (50 mg) in a package of 50 pieces.

     Storage: List B.

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