FEKSOFENADIN (Fexofenadine).

     4-[1-Oksi-4- [4-oksidifenilmetil] -1 - piperidinil] computers? ? - dimetilfeniluksusnaya acid.

     Issued as hydrochloride.

     Synonyms: Telfast, Allegra, Telfast.

     White or colourless crystalline powder. Poor water and soluble in chloroform, easy-to ethanol and methanol.

     Is metabolite terfenadina (see).

     As of terfenadinu very close to (see).

     In addition to the blockade N1- gistaminovyh stabilize membrane receptors fat cells (prevents the release of histamine and other mediators of allergy). There has antiholinergicheskoy activity.

     It has negative effects on the CNS.

     When you receive inside well and quickly absorbed, C max at 2.8 h; T? 14-h; devoted primarily with faeces unchanged.

     Protivogistaminny effect evolved through 1 h after administration, reaching a peak in 2-3 hours and lasts up to 12 hours

     Apply with allergic rhinitis, hay fever, hives and other allergic diseases.

     Assign adults and children, and children aged 12 years to 0.06 g (60 mg) two times a day.

     Side effects (weakness, dizziness, dispersion) occur rarely.

     Contraindications: age under 12 years.

     Form release: pills to 0.12 and 0.18 g (N. 10, 20, 30).

     Storage: List B.

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