FLORIMITSINA SULFAT (Florimycini sulfas).

     Florimitsin-antibiotic, a product life fragrant mushrooms floridae Streptomyces or other related organisms.

     Synonyms: Viomitsin, Florimycinum sulfuricum, Geliomycin, Vinactane, Viocin, Viomycinum sulfuricum, Vionactan.

     Powder or porous mass of white, or almost white, odourless, slightly bitter taste. Easy soluble in water.

     For chemotherapy properties similar to kanamycin (see). Provides specific bacteriostatic effect of Mycobacterium tuberculosis; Also active against gram and gram bacteria.

     Is <Reserve> drugs for the treatment of various forms of TB and localizations. His appoint patients whose number I tuberkulostaticheskie drugs have proved ineffective because of the development of resistance to them or for other reasons, as well as other anti-intolerance.

     Apply intramuscularly (in the bowel it is not absorbed). Enter (slow) deep in the upper outer Quadrant buttocks. Solutions for injection preparation before use; In gm vial containing 0,5-1, 0 g (500000 - 1000000 ED) drug, introduced W-5 mL of sterile water for injection, isotonic sodium chloride solution, or 0,25-0 , 5% solution of Novocaine. The solution should be used in the first days.

     Daily dose for adults is 1 year

     Enter daily to 0.5 g 2 times a day (morning and evening), or 1 1 g once a day for 6 days, 7-day break. With long-term care sometimes make a break for two days a week (or running through 2 - 3 days to one day).

     The highest single dose to vzrolyh 1 g, 2 grams daily dose for patients weighing less than 50 kg and those over 60 years of 0,5 0,75 g per day.

     The children florimitsina sulphate should be used with caution (because of the difficulties of assessing the impact of drugs on the ears). Assign it to children suffering from chronic destructive tuberculosis, and other inefficiencies.

     Daily dose for children 0,015 - 0,02 g (15 - 20 mg / kg) (no more than 0.5 grams for children and adolescents to 0.75 g).

     Please note that florimitsin can have toxic effects on the hearing nerve, and treatment should be carried out under the supervision of audiometry. At the first sign of a decrease in hearing preparation repeal.

     Florimitsin can be combined with drugs I and II series (PASK, Cycloserine, etc.). However, it can not be combined with streptomycin and other antibiotics, okaeyvayuschimi ototoksicheskoe Effects (neomycin, monomitsin, kanamycin and others).

     In applying florimitsina may have headaches, allergic dermatitis, protein in the urine.

     It should be borne in mind that in patients with kidney function violation vydelitelnoy florimitsina withdrawal from the body delayed, which could lead to its toxic action.

     Reducing neyrotoksicheskih and allergic reactions can use calcium pantotenata. (See).

     Contraindications: pair defeated VIII cranial nerves and violation of kidney function.

     Form release: in the hermetically ukuporennyh vials of 0.5 and 1 year

     Storage: List B. In a dry place at room temperature.

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