FLUDROKORTIZON (Fludrocortisone).

     Synonyms: Kortinef, Florinef, Alfanonidrone, Cortinef, Florinef, Fludronil and others.

     Chemical name: (11 Beta) -9 - Fluorine-11, 17,21 trigidroksipregn-4- - ene-3, 20-dione (in the form of 21-acetate)

     Pharmacology: Farmakologicheskoe action-mineralokortikoidnoe, glyukokortikoidnoe.

Increases AD, reabsorbtsiyu sodium, water and potassium secretion in kidney Channel. Oppresses a AKTG, function, stimulates glyukoneogenez, the breakdown of proteins (is a negative nitrogen balance), is immunodepressivnuyu and anti activity; While local application reduces itching and specified. Well absorbed from the digestive. Easily passes gistogematicheskie barriers. T1 / 2-18-36 h. Report the urine in the form of metabolites. Few ekskretiruetsya laktiruyuschimi milk glands.

     Application: Primary and secondary nadpochechnikovaya failure, adrenogenitalny syndrome expressed by the loss of electrolytes; Local in ophthalmic practice: Keratitis, allergic diseases and eye injuries.

     Contraindications: Hypersensitivity, cardiac failure, hypertension, hyper and hypothyroidism, osteoporosis, the violation of liver and kidney function, systemic and local MYCOSES, herpes, chronic infections, diabetes, ulcer disease divertikulit, mental disorders, pregnancy and breast-feeding; For local application - fungal and bacterial eye damage.

     Adverse actions: Nadpochechnikovaya failure, male, ZHKT erosion, improve glucose, giperkaliemiya, hypertension, headache, dizziness, euphoria, emotional Lability, increasing pressure vnutriglaznogo (inwards local), education cataracts (local), menstrual irregularities, slower growth in children, swelling.

     Networking: Improves efficiency (and toxicity), and systemic glyuko- mineralokortikoidov reduces - anabolic steroids (but also increases their hepatotoxicity), antidiabeticheskih oral drugs. Increased likelihood of side effects in the appointment of cardiac glycosides, means causing gipokaliemiyu (DIURETICS, amphotericin B B). While natriysoderzhaschih drugs increases the risk of infections and hypertension, acetylsalicylic acid and other NPVS - pitting mucosal stomach. Psychotropic and alcohol stimulates elimination.

     Overdose: Symptoms: daily, fiber, hypertensive Stroke, Eden, the increased body mass.

     Dosing and Administration: inside-from 0.1 mg three times a week to one every 0.2 mg per day. In nadpochechnikovoy chronic deficiency syndrome and adrenogenitalnom - 0,1-0,2 mg / day with hydrocortisone (10-30 mg / day), the long-term; Eye ointment: an age of 1-3 times a day, no more than two weeks.

     Precautions: A regular monitoring AD, the level of potassium and glucose in the blood. It should limit their intake of salt, pure potassium appoint drugs, control functions crust. Extension course possible only if lower doses. After a lengthy admission to gradually lifting (risk nadpochechnikovoy deficiency).

Materials allowed to copy only with the active hyperlink to the handbook of medicines