FLUFENAZIN (Fluphenazine). Triftormetil-10- 2 - (3-[1-(b-oksietil) - piperazinil-4] - propyl) fenotiazina digidrohlorid.

     Synonyms: Liogen, Liorodin, Mirenil, Moditen, Ftorfenazin, Anatensol, Dapotum, Elinol, Flumazine, Flumezin, Fluphenazini hydrochloridum, Fluphenazine hydrochloride, Lyogen, Lyoridin, Mirenil, Moditen, Pacinol, Pacinone, Permitil, Phthorphenazinum, Prolixin, Sevinal, Sevinol, Sevinon, Siqualine, Siqualone, Tensofin, Teviral, Trancin, Vespazin and gp.

     By building close to etaperazinu, but, like triftazinu contains 2 fenotiazinovogo nucleus of the group F P said. He has a strong adjunct and protivorvotnoy activity. In neyrohimicheskom mechanism of the drug is prevalent strong blocking effect on the central dofaminovye receptors with moderate impact on noradrenergicheskie receptors.

     Ftorfenazin antipsihoticheskoe has a strong effect, combined with a trigger (energeziruyuschim) effect. Bio act moderately and there is expressed at higher doses of drug.

     Ftorfenazin less active than triftazin in gallyutsinatornyh and delusional disorder.

     Apply ftorfenazin schizophrenia in different ways, particularly in malignant nuclear schizophrenia (gebefrenicheskoy, katatonicheskoy, early paranoid form), as well as some forms of periodic schizophrenia (depressivnoparanoidnoy, anxiety ipohondricheskih condition, etc.). The product is effective in schizophrenia with a long period. In small doses can be used with neurotic condition, characterized by fear, tension.

     In schizophrenia and other mental illnesses appointed interior, from 0,001 - 0,002 grams (1 to 2 mg) per day and gradually increasing the dose to 10 20 - 30 mg / day (3 - 4 reception at intervals of 6 to 8 h). In particularly resistant cases daily dose increased to 40 mg. After therapeutic effect dose gradually diminish and move on supportive therapy (1 to 5 mg / day).

     Intramuscularly introduce, as from 1, 25 mg (0.5 mL of 0.25% solution), 10 mg per day.

     In disorders of the interior to designate 1 - 2 mg (3 mg) a day (1 - 2 - 3 admission).

     Children dose reduced in accordance with age.

     When treating ftorfenazinom often can be observed on extrapyramidal disorders; Can develop spasmodic reactions, allergic phenomenon.

     The product is not designated for acute inflammatory liver diseases, cardiovascular diseases expressed decompensation, severe blood diseases, pregnancy and other contraindications to the use of derivatives fenotiazinovyh (see Aminazin).

     Method of production: tablets for 1; 2, 5 and 5 mg; 0.25% solution in the ampoule and 1 ml (2, 5 mg).

     Storage: List B. In sheltered from the world scene.

     Under the title <<Mirenil>> abroad issued digidrohlorid decanoate (ftorfenazina) in the form of Bean 0.25 and 1 mg (packing on 30 pieces); Called <<Moditen>> as Bean 1; 2, 5 and 5 mg (25 and 100 Bean in the package) and 0.25% solution of 1 ml ampoule.

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