GANTSIKLOVIR (Ganciclovir). 9 - (1, 3-Digidroksi-2- propoksimetil) Guanine, or [2-Gidroksi-1- (gidroksimetil) etoksi] methyl] Guanine.

     Available in a mononatrievoy salt.

     Synonym : Cymevene.

     White or almost white crystalline powder, soluble in water.

     Gantsiklovir is a new antiviral drug, close to the structure of th. Compared with aciclovir, gantsiklovir more efficient and, in addition, is not only the herpes virus, but the cytomegalovirus (CMV). In cells infected with CMV, gantsiklovir becomes first monofosfat, then trifosfat, which inhibits the synthesis of DNA and the replication of the virus.

     Infections caused by TSMV, often cause severe complications (retinity, pneumonia, colitis, etc.) in patients with immunodeficiency states, including the acquired immunodeficiency syndrome (AIDS), since the operations of organ transplantation and bone marrow, chemotherapy neoplasms . Gantsiklovir is one of the first drugs proposed for the treatment of the complications.

     Gantsiklovir applied in the form of intravenous infusions. Enter usually at the rate of 5 mg / kg at a constant speed for one hour every 12 hours for 14 to 21 days (patients with impaired renal function).

     Patients with immunodeficiency condition and the risk of relapse of retinitis introduce 6 mg / kg / day, 5 days a week or 5 mg / kg per day every day.

     When treating gantsiklovirom can develop neutropenia and granulotsitopeniya, it is therefore necessary to closely monitor the treatment of blood picture. Perhaps drug side effects on cardiovascular and nervous system, gastrointestinal tract, sometimes skin itch, Alopecia and others.

     The drug is contraindicated in pregnancy and breastfeeding, high sensitivity edition.

     Caution should be exercised in patients with impaired renal function : The drug mainly devoted to the violation of urine and excretory functions of the kidneys down considerably reduced.

     There should be appointed gantsiklovir conjunction with other drugs, causing neutropenia. If there is no pressing need, it would be inappropriate to combine gantsiklovir hosting other medicines.

     Solutions are gantsiklovira alkaline reaction (pH 9, 0, 11, 0); They should be strictly non slowly.

     Product : in the form of dried powders in vials containing 0,546 grams (546 mg) gantsiklovira sodium, which corresponds to 0.5 g (500 mg) gantsiklovira grounds.

     Solutions to produce sterile water for injection immediately before use. Ready solution can be stored in the refrigerator for 24 hours

     Storage : Keep in a cool place protected from the light.

Materials allowed to copy only with the active hyperlink to the handbook of medicines