Gangleron (gangleronum)
GANGLERON (Gangleronum). g-Dietilamino-1, 2-dimetilpropilovogo parameters izobutoksibenzoynoy acid ester hydrochloride.
Synonym : Ganglefeni hydrochloridum.
Colorless crystalline powder and odourless. Gigroskopichen. The easily soluble in water and alcohol. The solutions (pH 4, 5, 6, 0) + 100 to sterilize 'C for the PC min.
Gangleron has holinoliticheskoe, and mestnoanesteziruyuschee spasmolytic effects.
Lock-n-holinoreaktivnye system vegetative nodes (parasimpaticheskih and sympathetic) and the central nervous system, the m-holinoreaktivnye system does not have influence; Is smooth muscle relaxation and increased blood vessels.
It may be used as a tool in various stages of pathological conditions involving smooth muscle spasm, including abdominal muscles, and to prevent strokes. There are performance ganglerona with simpatoganglionitah and gangliosolyaritah.
Assign gangleron inside, under the skin or intramuscularly. In Vein not be possible because of the sharp depreciation of AD.
Inside are capsules of 0.04 g 3 - 4 times a day. Under the skin and enter intramuscularly in the form of 1, 5% solution, starting with 1 ml of 3 - 4 times a day (in the first 1 - 2 days), then on 2 - 3 ml of 3 - 4 times a day. С 10-го дня лечения заменяют одну инъекцию приемом препарата внутрь до еды и в течение 4 дней полностью переходят на прием препарата внутрь. The total duration of treatment 4 - 5 weeks.
Sometimes also used for intradermal gangleron blockade (with insufficient subcutaneous or intramuscular injection). Instead, regular injections of the drug inside or reception, make intradermal blockade, using 0,2 - 0,25%, solution preparation, the next day doing bilateral paravertebralnuyu blockade of T h-1 T h 5.
Высшие дозы для взрослых внутрь: разовая 0,075 г, суточная 0,3 г; под кожу и внутримышечно: разовая 0,06 г (4 мл 1, 5 % раствора), суточная 0,18 г (12 мл 1, 5 % solution).
Gangleron usually well. When he gets into is feeling irritation easy to follow anesthesia. В концентрациях свыше 1, 5 % препарат нельзя применять для инъекций, так как он может вызвать раздражение и некроз тканей.
Method of issuance : 1, 5% solution in 2 ml ampoules; Capsules of 0.04 g.
Storage : List B;
R p. : Sol. Gangleroni 1, 5% 2 ml
D.t.d. N. in ampull 10.
S. At 1 ml intramuscular injection 3 times a day
R p. : Gangleroni 0.04
D.t.d. N. in 50 caps.
S. At 1 capsule 3 to 4 times a day
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