GLIBUTID (Glibutidum).

     Butilbiguanida hydrochloride.

     Synonyms : Adebit, Silubin, Adebit, Buformin hydrochloride, Buformini hydrochloridum, Butylbiguanid, Butylnite, Gliporal, Glybigid hydrochloride, Krebon, Silubin and others.

     The white crystalline powder bitter taste. The easily soluble in water and alcohol.

     Referring to the synthetic oral hypoglycemic drugs (antidiabetics) biguanidov group.

     Top hypoglycemic effect is through 4 - 5 h after administration of the drug.

     Applied for the treatment of type II diabetes in adults. Coupled with the use of insulin in diabetes insulinorezistentnyh forms, as well as resistance to the drugs antidiabetics sulfonylureas, and minor forms of diabetes, accompanied by obesity, and in patients receiving treatment with insulin, in labile during diabetes.

     Glibutid as other biguanidy (metformin and others) to oral antidiabetics drugs, which are significantly lower body mass in patients with diabetes, and obesity. These drugs lower the appetite, increase the anaerobic Glycolytic, reduce intake of glucose from the gastrointestinal tract, and have antilipidnoe fibrinoliticheskoe effect.

     Assign food inside at the time. As protivodiabeticheskogo means taking from 0.1 g / day (50 mg morning and evening); Depending on the change of glucose in the blood and urine dose can be gradually increased to 50 mg / day, but daily intake should not exceed 300 mg.

     Supported dose is usually 50-100 mg 50 mg morning and evening.

     In combination with insulin dose last gradually under the control of glucose in the blood and urine.

     But drugs sulfonylureas glibutid appointed when the first fails to reduce giperglikemiyu glyukozuriyu and to the required levels.

     In the treatment of obesity glibutid are usually 0.1 grams a day (often in combination with stimulants drugs).

     Glibutid well tolerated, but could experience a loss of appetite, nausea, vomiting, diarrhea, metallic taste in his mouth. At a later date from the beginning of treatment (a month or more) may be weak, lower body mass.

     Side effects are usually quickly with dose reduction or elimination of the drug.

     Contraindications to the use glibutida are : absolute testimony to the use of insulin, the body in the absence of endogenous (or input exogenous) insulin, komatoznye state disorders, infections, hypertensive motivated diabetic nephropathy, liver failure, diabetic angiopatiya provision for the development of inflammation, gangrenous limbs , pregnancy.

     It should be borne in mind that some patients in the application biguanidov can develop ketoz disorders and reducing reserve alkalinity of blood (higher risk development molochnokislogo disorders marked by the application of the drug "Fenformin : 1-fenetilbiguanid).

     In the case of drugs ketoza overturned. When treating biguanidami, especially in the initial period, it is necessary to examine the urine of the content of acetone. Further definition ketonovyh phone to about 1 week.

     Product : pills to 0.05 grams in a package of 50 pieces.

     Storage : List B. In dry place.

     In Germany issued drug prolonged action buformin ointment (Buformin retard), a pill containing 0.17 g buformina tozilata (paratoluolsulfonata), or 0.1 grams of a substance (butilbiguamida). Assign first one pill (morning), gradually increasing the dose of 4 tablets (morning and evening after eating).

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