GRANDAKSIN (Grandaxinum). 1-(3, 4-phenyl Dimetoksi-) -4 - metil-5- ethyl-7, 8-dimethoxy-5 H-2, 3-benzodiazepine.

     Synonyms : Tofizopam, Tofizopam, Tofizopamum.

     Description : White to yellowish sheen crystalline powder. Almost nerastvorim in water, soluble in alcohol difficult.

     Pharmacology : The drugs act-acid, stimulating.

GAMKmimeticheskie enhance processes in the CNS. Has vegetokorrigiruyuschey and stressprotektivnoy activity not accompanied by a pronounced sedative, and miorelaksiruyuschim convulsants action. Expands coronary vessels.

Quickly and completely absorbed from the digestive tract, Cmax achieved after 2 hrs, T1 / 2 at 6-8 h formed biotransformation products anksioliticheskogo not have influence. Write with urine (60-80%) in the form glyukuronidov, the remaining 20% excreted in faeces. Not kumuliruet.

     Application : Neuroses, Psychopathy, patoharakterologicheskoe personal development; State, accompanied by emotional stress, vegetative disorders, fear, apathy, decreased activity, brassy feelings; Reactive depression with moderately expressed mental symptoms, lack of initiative, weakness, kardialgiya (alone or in combination with Dr. . drugs), strokes, delirioznye state (for the lifting of the institution and vegetative symptoms), alcohol abstinence, menopausal syndrome; male, myo, neurogenic muscular atrophy and other conditions are secondary neurotic symptoms, which can not receive miorelaksiruyuschim scored with a pronounced effect.

     Contraindications : Giperchuvstvitelnost, psychosis and with the expressed Psychopathy psychomotor excitation, aggressiveness or deep depression, asthma respiratory failure, exanthema, pregnancy (especially I and III trimester), breast-feeding (the period of treatment ceased), engaging in vigorous activities that require concentration and quick response (if there is no possibility of release from work).

     Side Effects : Psihomotornoe excitation, irritability, aggression, high anxiety, sleep disturbances, nausea, gastralgii, skin itch, exanthema.

     Networking : Deprimiruyuschie funds increase (each) oppression CNS. Metoclopramide accelerates offensive effect (increasing velocity absorption due to increases peristalsis of the bowel).

     Overdosing : Symptoms : deep sleep, coma development.

Treatment : restoring respiratory and cardiovascular activity.

     Dosing and Administration : inside 50-100 mg / day (maximum dose of 300 mg) in the reception 1-3 over 4-12 weeks, including the time phasing out the drug. The children, the elderly and the sick somatic dose reduced by 2 times.

     Precautions : If affektivno- state of shock and deep depression monotherapy is not recommended, because possible masking symptoms and inhibiting diagnosis (using aggressive combination therapy with antidepressants). Finished treatment gradual decline in single and daily doses (prevention syndrome cancellation). Standing medical monitoring requires the appointment of patients with myasthenia.

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