GRIZEOFULVIN (Griseofulvinum).

     Antibiotics, produtsiruemy mould fungus Penicillium nigricans (griseofulvum). On the chemical structure of a 7-hlor2 ', 4, 6-trimetoksi-6'- metilgrizen-2'- dione-3, 4'.

     Synonyms : Gritsin, Biogrisin, Fulcin, Fulvicin, Fulvina, Fulvistatin, Fungivin, Greosin, Gricin, Grifulin, Grifulvin, Grisactin, Grisefuline, Grisovin, Lamoryl, Likuden, Neo-Fulcin, Sporostatin and others.

     Griseofulvin is anti means providing fungistaticheskoe effect on the different types dermatomitsetov (trihofitony, mikrosporumy, epidermofitony).

     Ineffective with candidiasis. An important feature is grizeofulvina its effectiveness when administered.

     Grizeofulvina activity to a certain extent, depends on the dispersion of crystals and related specific surface powder. Normal melkokristallicheskaya formulation approximately 2 times less active than producing a specially manufactured, previously called griseofulvin forte.

     Currently used mainly producing drugs, which most of the particles is not more than 4 microns.

     The drug is a white, or white with a yellowish sheen naimelchayshy crystalline powder with low specific smell (mushroom). Almost nerastvorim in the water, little is soluble in alcohol.

     Griseofulvin is one of the main means of treating patients dermatomycosis. His designated for the treatment of patients suffering favusom, trihofitiey and mikrosporiey nails head and smooth skin epidermofitiey smooth skin caused by trihofitonom and defeat Nail (onihomikozami) caused by pathogenic fungi (trihofiton, red epidermofiton).

     Is griseofulvin interior and local.

     To be accepted into the form of tablets (to 0,125 g) and a suspension (1 ml of 0.1 g grizeofulvina); For local applications, such as 2, 5% linimenta.

     Pills are inside during meals (1 tea spoon of oil). Suspension is intended for children under 3 years of age. Liniment used independently with limited damage skin and combined with the admission of the drug inside.

     In mikrosporii designate an adult to eight pills a day, the children - an estimated 21 to 22 mg / kg per day. The preparation took a day before the first negative review of mushrooms, then in the same dose over two weeks through the day and 2 weeks, 2 times a week.

     In trihofitii (surface and infiltrativno- nagnoitelnaya forms) and favuse, adults designate the same dose, children under 18 mg / kg (the same pattern).

     In the treatment of patients with mycosis nails head to weekly sbrivat hair, the head of water to wash with soap two times a week. Recommended chafe at the head-containing skin creams and obscure pockets of 2 to 3% alcohol solution of iodine.

     In onihomikozah, trihofitii and favuse nails of the head, grizeofulvina daily intake for adults weighing up to 50 kilograms of 5 tablets (625 mg), and with greater body weight adds to the 10-kg-1 pill, but not more than 1 g (8 the tablets) a day.

     Children and adolescents are designated with onihomikozah to 16 mg / kg per day.

     In onihomikozah take medication in the first month, every day, the second day of the month-through, then two times a week. The total duration of treatment of at least 8 mo.

     In onihomikozah recommended treatment grizeofulvinom combined with the removal of nails keratoliticheskimi means, and apply antigribkovye drugs.

     Liniment cause thin layer of areas affected in the daily intake of no more than 1930 treatment continue at least two weeks after the disappearance of clinical symptoms and negative results in three microscopic examination.

     In applying grizeofulvina possible diarrhoeal phenomenon, headache, nausea, dizziness, disorientation phenomenon, urticaria. Sometimes developed eosinophilia, radiation, less leucocytosis. In these cases to a break in treatment for 3 to 4 days; In light enough cases to reduce the daily dose of over 4 to 5 days. In urticaria should take into protivogistaminnye drugs, 10% calcium chloride solution, as nausea, inside the cafeteria spoon 0.5% solution of novocaine.

     Recommended appoint sick vitamins : ascorbic acid, thiamine, riboflavin, nicotinic acid; One in every 10 to 15 days to do blood tests.

     Contraindications : expressed radiation and systemic diseases of the blood, liver organic disease and kidney porfirinovaya disease, malignant neoplasms, pregnancy, breast-feeding.

     The drug should not appoint outpatient drivers transport pilots, who are employed in high-altitude work.

     In diathesis and diabetes should not appoint suspension (of the content in sugar).

     Method of issuance : pills to 0,125 g; Suspension of 100 ml in the banks of glass with plastic screw caps; Liniment (2, 5%) of PC g banks orange glass.

     Storage : List B. In dry place at room temperature.

     Rp. : Tab. Griseofulvini 0,125 N. 40

     D.S. At one tablet four times a day

     Rp. : Susp. Griseofulvini 100 ml

     D.S. For one dessert spoon three times a day (children 10 years old)

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