GIDROKSIMOCHEVINA (Hydroxyurea).

     Oksiproizvodnoe urea (see).

     Synonyms : Gidrea, Gidroksikarbamid, Hydrea, Biosupressin, Hidrix, Hydroxycarbamide, Hydroxycarbamidum, Hydura, Litaliz, Onco-carbamidi.

     As chemical compound gidroksimochevina was synthesized in 1869, and only in 1982 was proved its clinical effectiveness of the treatment of some forms of cancer.

     Gidroksimochevinu applied for the treatment of chronic mieloleykoza, infection, melanoma, and breast cancer.

     The mechanism of anticancer compounds on the ability ribonukleoziddifosfatreduktazu inhibition, which is a key enzyme involved in DNA biosynthesis.

     Preparation is easily absorbed by ingestion, the peak concentration in plasma observed in 1 - 2 h period polususchestvovaniya about 2 hours Passes through the blood-brain barrier. About 80% is allocated to the urine over 12 hours

     Is inside capsules containing 0.5 g gidroksimocheviny. Usually appoint one capsule 3 to 4 times a day. The course of treatment 3 to 4 weeks. There are also other schemes treatment (80 mg / kg 1 every 3 days; 20 - 30 mg / kg daily; The duration of treatment 6 weeks).

     The drug is usually well. Perhaps the development of diarrhoeal events, allergic skin reactions, rarely stomatitis, as well as radiation, megaloplasticheskoy anemia, thrombocytopenia.

     Side-effects are usually quickly after receiving the drug.

     Gidroksimochevina not suitable for serious violations of bone marrow function, severe anemia and expressed radiation, through breastfeeding,

     Product : capsules to 0.5 g in a package of 100 pieces.

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