INTERFERON GAMMA (Interferon gamma)

 

      Synonyms : Ingaron, recombinant human Interferon gamma

 

      The drugs act : Interferon gamma is glikoprotein with molecular mass of 20-25 kDa and known as immune interferon. Received from induced human T-lymphocytes. Currently, for interferon gamma increasingly used recombinant DNA methods using bacterial cells. We know two types of interferon gamma-gamma 1 and gamma 2 as a distinct sequence of amino acids in the chain of 139 one and the situation. Has pronounced ummunomodulating activity, as well as increased expression of HLA antigens much I and Class II; Activates makrofagi increased activity of natural killers; Reduced expression of sub B-cells, monocytes and Eosinophils induced IL-4; As well as reducing JgE products; Stimulated the growth and differentiation of B-cells.

 

      Indication : Psoriasis; As maintenance therapy with cutaneous and visceral leishmaniasis; Mikobakterialnaya HIV-negative infection in patients with poor conservative therapy; Leprosy; As an alternative therapy in rheumatoid arthritis. Atopic dermatitis, and atopic dermatitis, particularly in the high-JgE. As an additional means to antibiotikoterapii chlamydia a.

 

      Contraindications : Pregnancy.

 

      Side Effects : Frequently - grippopodobny syndrome, but may be expressed fever, shivers, mialgii, fatigue, weakness, drowsiness, weight loss, nausea, neutropenia and thrombocytopenia, raising transaminaz, Alopecia, skin itch, the polymorphic rashes.

 

      Special instructions : When sharply expressed by local and systemic reactions treatment should be discontinued if severe side effects to be applied kortikosteriody edema.

 

      Dosing and Administration : Dose set individually depending on the evidence and endurance therapy. Enter in / m, p / c and v /.

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