IRBESARTAN (Irbesartan).

     2-Butyl-3 [couple (ortho-H TETRAZOL ilfenil 1) benzyl] -1,3 - diazaspiro [4,4] non-1- en-4- it.

     Synonym : Aprovel, Aprovel.

     Is irreversible blokatorom AT1- angiotenzinovyh receptors.

     Quickly and completely absorbed in the digestive tract, bioavailability of 60-80%, C max 1,5-2 h, T? - 11-15 h; biotransformation exposed in the liver, displayed mainly in feces and bile.

     Applied with arterial hypertension and congestive heart failure.

     Assign inside of 0.15, or 0.3 grams (0,075 older-d) 1 per day.

     Possible side effects : headache, dizziness, weakness, fatigue, tachycardia, neuralgia, mialgiya, urticaria, etc.

     The drug is contraindicated in pregnancy and breastfeeding.

     Product : pills to 0,075; 0.15 and 0.3 g (N. 14, 28).

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