IRINOTEKAN (Irinotecan).

     (+) -7 - Ethyl ether 10-oksikamptodetsin-10- (1,4? - bipiperidin) -1? - carboxylic acid (hydrochloride).

     Synonyms : Kampto, Campto, Camptosar.

     Pale yellow or yellow crystalline powder. Mg in water and organic solvents.

     Semi derived alkaloid kamptotetsina, extracted from the stems of shrubs Campotheca acuminata.

     Ingibiruya DNA-topoizomerazu I block the replication of DNA in S-phase cell cycle.

     When applied metastaziruyuschem cancer ablation (colon cancer) in the absence of the effect of 5-ftoruratsila and in light of cancer, ovarian and cervical cancer.

     Enter intravenously (over 30 minutes) at a rate of 0.35 g / m 2 1 every 3 weeks.

     Possible side effects : severe holinergichesky syndrome (sweating, Tear and salivation, diarrhea, the first day after Infusion), diarrhoeal phenomenon, stomatitis, unconscious contraction of muscles, paresteziya, Alopecia, fever, neutropenia, radiation, thrombocytopenia, anemia, skin allergic reactions.

     Contraindications : chronic ulcers, neutropenia, pregnancy, breast-feeding.

     Product : 2% solution for infusions in bottles of 2 and 5 ml.

     Storage : List B.

Materials allowed to copy only with the active hyperlink to the handbook of medicines