ISRADIPIN (Ispradipine) *.

     M 4-methyl ether (4-benzofurazanil) -1, 4-digidro-2, 6 dimethyl-3, 5-piridindikarbonovoy acid.

     Synonyms: Lomir [name of the drug company Sandoz (Switzerland), Lomir, Isrodipine.

     According to the chemical structure and pharmacological properties similar to other ions of calcium antagonists group 1, 4-dihydropiridine. It is the expansion of blood vessels and skeletal musculature heart arteries and the brain.

     The product reduces blood pressure and has a moderate effect natriyureticheskoe; Well absorbed from the gastrointestinal tract; Found in blood plasma in 20 minutes after receiving inside, the maximum concentration is approximately 2 hours

     Assign isradipin with light and medium forms of hypertension by 0.0025 g (2, 5 mg tablet = 1) 2 times a day. Reducing the AD is usually in the first week of treatment, and the maximum effect was through 3 to 4 weeks. With inadequate dose increase to 5 mg 2 times a day. Isradipin can be used in combination with other drugs antigipertenzivnymi.

     Possible side effects associated primarily with sosudorasshiryayuschimi properties drugs: dizziness, headache, skin redness, nausea, peripheral swelling; Perhaps feeling of fatigue.

     The product should not be appointed to pregnant and breast-feeding. There is enough experience with the drug in children. In violation of the liver and kidneys, with chronic heart failure, weakness sinusnogo node requires caution.

     Tsimetidin (see), and other inhibitors of liver enzyme activity (Cytochrome P-450) increased bioavailability isradipina; In the case of the simultaneous application of tsimetidinom, isradipina dose should be reduced by half.

     Form release: tablets, containing 0.0025 g (2, 5 mg) isradipina.

     Storage: List B.

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