LEYPRORELIN (Leuprorelin).

     Synonyms : Lyukrin depot, Prostap, Lucrin depot, Prostap.

     6-D- Leytsin-9- (N-etil-L- prolinamid) -10 - deglitsinamid- Luteinizing gormon- rilizing- factor (swine).

     Analogous gonadotropin- rilizing- factor.

     Available in the form of acetate (C59H84N16O12 · C2H4O2).

     As of close to buserelinu (see).

     After intramuscular introduction leyprorelin released from the copolymer during 1 month, while during the first 7 days of sex hormones increases, and by 21-28 th day decline and remained at that level in subsequent introduction of the drug.

     Bioavailability of 75-98% T? - 3 hours

     When applied gormonozavisimom prostate gland cancer, as well as in fibromioma uterus and endometriosis.

     Available in the form of freeze-dried microspheres in vials of 3.75 and 7.5 mg together with the solvent. Diluted impose subcutaneously or intramuscularly 1 per month : the prostate gland cancer, 3.75, or 7.5 mg; When fibromioma uterus and endometriosis - 3.75 mg. The course of treatment is not more than 6 months.

     Possible side effects : headache, dizziness, sleeping, neuralgia, swollen face and legs, visual and hearing impairment, depression, reduced libido; For men, impotence, Bitch, reducing eggs; Women-vaginitis, skin, girsutizm, lower density bone.

     The drug is contraindicated in gormononezavisimom cancer prostate gland.

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