LIDOFLAZIN (Lidoflazinum) *. 4-[4, 4 - Bis (para-fluorophenyl) - butyl] -1 - piperazinil- atseto-2 ', 6'- ksilidid.

     Synonyms : Klinium, Clavidene, Clinium, Corflazine, Klinium, Klintab, Ordiflazine.

     White-crystalline substance. Nerastvorim almost in the water.

     The drug is a complex structure : on the one hand, it is close to neuroleptic-flushpirilenu pimozidu and (see), on the other hand, can be seen as derivative ftorsoderzhaschee fenilalkilamina whose amino side chain substituted analogue piperazinovym lidocaine (see); Some close also flunarizinu (see).

     Lidoflazin increasing coronary vessels and increase coronary blood flow; In long-term use kollateralnoe improves blood circulation.

     At AD, frequency and force of heart will not have a significant impact.

     The mechanism of the drug is linked to the apparent effects on vascular smooth muscle and potentiation of koronarorasshiryayuschego formed in attack adenosine.

     Applied with chronic coronary insufficiency to prevent strokes. There is evidence that the drug is more effective when voltage strokes than the more severe strokes, tension and peace.

     Assign inside (after eating) tablets (60 mg), beginning 1 1 pill once a day (during the week), then one pill two times a day (in the second week) and then one tablet three times day. The course of treatment up to 6 months.

     In applying the drug may headache, dizziness, noise in the head, sometimes temporary digestive disorders.

     Contraindications : distributed atherosclerosis of coronary vessels, the acute phase of myocardial infarction, violation of rhythm and conduction heart pregnancy.

     There is a need to be cautious about the appointment lidoflazina with cardiac glycosides and other drugs, which can cause heart rhythm violations.

     If admission to lidoflazina ECG interval was extended Q-T or appear zheludochkovye ekstrasistoly need to reduce the dose or stop the reception.

     Product : pills to 0.06 g (60 mg) in a package of 50 and 200 pieces.

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