MANNIT (Mannitum).

     Is shestiatomnym alcohol; One of the group of sugars.

     Synonyms : Mannitol, Aerosmosol, Diosmol, Isotol, Manicol, Manitol, Mannidex, Mannigen, Mannistol, Mannitol, Mannyl, Osmitrol, Osmosal, Rectisol, Renitol.

     For medical applications issued Mannitol for injections (Ma nnitum pro injectionibus). Mass smallpox light amber. Mg in the water, easy-to hot.

     Hypertensive solutions mannitol diureticheskoe have a strong effect. The effect is due to increased osmotic pressure plasma and lowering water reabsorption. Diuretichesky effect for a large quantity of water that separates Mannitol other osmotic diuretikov, particularly urea. The drug does not affect the klubochkovuyu filtering. Diurez a large allocation of sodium without significant impact on vydedenie potassium. The effect is all the more concentration of the drug. If the kidney filtering function diuretichesky effect can otsutstvavat.

     Mannitol applied in the form of 10 - 15 - 20% solution vnutricherepnogo downward pressure and reduce swelling of the brain, severe kidney or liver failure Renal saved with the kidneys filtering capacity and other conditions requiring increased diureza. In acute glaucoma may long for the dehydration of mannitol (see Urea).

     In connection with degidratiruyuschim action and the decline vnutricherepnogo pressure to appoint the intensive therapy convulsant status.

     Mannitol is also recommended for use in operations with the artificial blood to prevent ischemic kidney and related acute renal failure. The preparation ensures greater breeding white liquid, reduces renal vascular resistance and usilvaet in the bloodstream, contributes to the withdrawal nefrotoksinov. The drug is also effective in the administration of barbiturates.

     Enter Mannitol intravenous (struyno slow drip). Applied finished 15% solution or 10 - 15 - 20% solutions, cooked ex tem ro r e : 10% solution can be prepared at room temperature, 15% and 20% solutions in the fuel-water bath for up to 37 C. Mannit dissolve in sterile water for injection or 5% glucose solution. Solutions must be discoloured, transparent, odourless.

     From prevention to give occasional dose rate of 0.5 g / kg, with curative - 1 - 1 5 g / kg. Daily intake should not be more than 140-180 g.

     In operation with the artificial (extra) in the circulatory system just before the white impose 20-40 g mannitol.

     Contraindications : Violations of renal excretory function and severe circulatory insufficiency. With the introduction of excess body mannitol there may be signs of dehydration (diarrhoeal phenomenon, hallucinations, etc.). To avoid dehydration are needed in the body fluids (see Urea). Mannitol should re-entered controlled water-salt balance.

     The drug was not effective in azotemii in patients with cirrhosis of the liver and cirrhosis.

     Method of issuance : in bottles with a capacity of 500 ml, sealed with rubber and metal bottle caps containing 30 grams of the drug; 15% solution in ampoules of 200,400, or 500 ml.

     Storage : dried Mannitol store under normal conditions, 15% Solution in temperature is not above 25 'C.

Materials allowed to copy only with the active hyperlink to the handbook of medicines