MEDILAZID (Medilasidum).

     Crystal individual cardiac glycoside, derived synthetically field-by Methylation digoxin. Contains more Ò group in the sugar balance (D digitoksoza).

     Synonyms : Bemekor, b Metildigoksin, Bemecor, Bemekor, Digicor,

     Lanitop, Medigoxin.

     White or white to slightly yellowish sheen crystalline powder.

     Almost nerastvorim water, it is difficult to alcohol.

     On biological activity (kardiotonicheskoy) medilazid close to the digoxin; 1 g product contains GED 2100 - 2700 2200-2900 or KED.

     According to the application close to the digoxin.

     Distinguishing Features pharmacokinetics medilazida BAS with a rapid ingestion (through 5-25 minutes); Kardiotoni dollars to reach a peak after 50-60 min after administration. When intravenously effect begins to emerge through the 1-5 minutes. Compare UNESCO with other glycosides lapidary drug's lesser cumulation; After the duration of exposure is 3 to 9 days, digoxin-6-9, digitoksina-14-21 days'.

     When applied in various forms of chronic heart failure, as a permanent form mertsatelnoy tahiaritmii, paroxysmal oils and flicker predserdy, supraventrikulyarnoy paroxysmal tachycardia.

     Medilazid appointed interior adults (regardless of the meal).

     Dose picked strictly individuvlno. There are 3 ways of digitizing : fast, moderately fast and slow. To obtain a rapid therapeutic effect using rapid saturation medilazidom phased in over 24 h 36 (fast type of saturation). This initial dose of 0.8-1.0 mg followed by the addition of 0.1 - 0.15 mg every 5 to 6 hours to obtain the optimal therapeutic effect. Then move on maintaining dose (0.1 - 0.4 mg / day).

     For moderately fast digitisation drug appointed in the first-WTO are the third-day dose of 0.6 - 0.8 mg (0.2 mg for 3 to 4 times a day) in the fourth, fifth and sixth-0,4-0 , 6 mg (0.2 mg of 2 - 3 times a day).

     Then move on to supporting dose-0.1 - 0.4 mg (an average of 0.2 mg / day).

     To slow digitizing medilazid provide within 10 days a dose of 0.4 - 0.6 mg (0.2 mg of 2 - 3 times a day), later moving to support dose (0.1 - 0.2 mg / day ).

     Higher daily doses of 1, 25 mg.

     According to the collateral and contraindications close to the other patients there lapidary.

     Product : pills to 0.0001 g (0.1 mg) in a package (tubes) for 50 pieces.

     Storage : List A. In the dark spot.

     A medilazidu foreign drug bemekor issued in the form of injectable solution of 2 ml (0.2 mg for b-metildigoksina), and in the form of drops reception inside containing 1 ml (45 drops) 0.6 mg b-metildigoksina. Ampoules using the rapid saturation.

     In levozheludochkovoy acute heart failure and paroxysmal tachycardia supraventrikulyarnoy saturating dose of 0.2 mg (1 vials) intravenously 3 times a day for 2 to 3 days supporting dose of 0.1 - 0.4 mg per day. Supportive therapy are usually supplies drugs inside in the form of tablets or drops.

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