MEDROKSIPROGESTERONA acetate (Medroxyprogesterone acetate). 17-6-Gidroksi a metilpregn-4- - ene-3, 20-acetate glows.

     Synonyms : Depo-Provera, Provera, Farlutal, Clinovir, Depcorlutin, Depo-Alphacort, Depo-Clinovie, Depo-Promone, Depo, Farlutal, Farmolut, Gestopuran, Luteodione, Metilgestene, Neolut, Nidaxin, Normobion, Onco-Provera, Prodafem, Promone-E, Provera, Proverone, Sedometril, Vadecin and others.

     On chemical structure similar to progesterone derivative (see) in the main action is progestinom (gestagenom). As gestagennoe tool is the application of the menstrual irregularities, dysfunctional uterine krovotecheniyah. However, the use of anticancer drug is as a means to gormonochuvstvitelnyh malignancies (see Progesterona kapronat), especially in breast cancer and cancer of the uterus (endometrium). The effect is not only gestagennoy but with antiestrogennoy, antiandrogennoy and antiagonadotropnoy activity.

     When breast cancer marked correlation between efficiency and medroxyprogesterone of estrogen and progesterone receptors in neoplastic tissue.

     The drug can be used as monotherapies or combined with antiestrogenami (see) or cytostatica.

     As an antitumor means medroxyprogesterone acetate used mainly for additional or (and) palliative therapy and relapse (or) endometrium cancer and kidney cancer as well as therapy for relapse gormonalno- dependent breast cancer among women postmenopauze.

     Drug use inside or intramuscularly.

     The drug medroxyprogesterone Provera appears in two forms : a) tablets Provera and b) suspension Depo Provera.

     Pills Provera appointed interior with the endometrium cancer and kidney from 200 to 600 mg per day, with breast cancer-from 400 to 1200 mg per day. The effect was usually 8 to 10 weeks from the start of treatment.

     Depo-Provera impose intramuscularly in the form of slurry (150 mg drug in 1 ml) in the endometrium and kidney cancer in 1000-400 1 mg once a week. In improving to reduce the dose of 400 mg, and introduce a 1 per month.

     When breast cancer impose on 500 mg daily for 28 days, followed by 500 mg 2 times a week to maintain the effect.

     If the disease therapy medroxyprogesterone acetate stop (the same as in similar products).

     Possible side effects and contraindications are basically the same as the application of other gestagenov.

     If possible suspension compression and sterile abscesses at the injection.

     Method of issuance : 100 tablets; 200; 250; 400 mg (0.1; 0.2; 0.25; 0.4 g); Suspension for reception inside containing 500 mg in 1 ml : Suspension for intramuscular injection (depot - Provera) in vials of 3, 3 ml (500 mg or 150 mg in 1 mL) and 6, 7 ml (1000 mg).

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