MELLIKTIN (Mellictinum).

     Melliktinom called gidroyodid metillikakonitina alkaloid contained in plants animals setchatoplodnaya (Delphinium dictiocarpum), animals poluborodataya (e lphinium semibarbatum D), etc., hares family (Ranunculaceae).

     On chemical structure of the akonitovym alkaloids. This tertiary base of C 37 H 50 N 2 O 10. White or white with low amber or pink shade melkokristallichesky powder. Malorastvorim in water and alcohol. In light yellow.

     Melliktin has kurarepodobnymi properties. According to the mechanism of nerve-muscle conductivity close to the d-tubokurarinu.

     Unlike d tubokurarina, diplatsina and other similar drugs melliktin does not contain a molecule quaternary nitrogen atoms, it is absorbed in giving stomach and has in this way of introduction, as well as with the parenteral use, blocking effect on nervnomyshechnuyu conductivity. Melliktina antagonists are Neostigmine and other anticholinesterase substance (Galantamine).

     The drug has also moderate ganglioblokiruyuschee effect.

     Applied to decrease muscle strength in the pyramid insufficient vascular inflammation and origin postentsefaliticheskom parkinsonizme disease and Parkinson's disease Little, arahnoentsefalite and spinal Arachnoiditis and other diseases pyramid and ekstrapiramidnogo character, a raise of muscle strength and motor function disorders.

     Assign inside of 0.02 grams from 1 times and bringing up to five times a day. The course of treatment for three weeks to 2 months. After a 3 - 4-month interruption of treatment again. Treatment melliktinom combined with the testimony of other methods of treatment and physiotherapy.

     The drug is not suitable for infants and other diseases, along with the declining muscle strength, in violation of the functions of the liver and kidney as well as in cardiac decompensation activities.

     When the correct dosage melliktin postponed without side effects. In cases of hypersensitivity to the drug or overdose and feelings of weakness or depressed respiration be artificial ventilation lung appoint oxygen and slowly introduce semi - 0.5 1 ml 0.05% solution prozerina together with atropine (0.5-1 ml 0.1% solution). Treatment must be carried out under the close supervision of a doctor.

     Product : pills to 0.02 g (20 mg).

     Storage : List A. In the dark spot.

Materials allowed to copy only with the active hyperlink to the handbook of medicines