MERKAZOLIL (Mercazolilum). 1 - Methyl merkaptoimidazol.

     Synonyms : Tiamazol, Antiroid, Basolan, Danantizol, Favistan, Mercazole, Methimazole, Methothyrin, Tapazole, Thiamazole, Thycapzol, Thymidazol and others.

     White or yellow crystalline powder with low specific smell and taste. The easily soluble in water (1:7, 5) and alcohol (1:10).

     Is synthetic antitireoidnym (tireostaticheskim) substances. Like other substances in this group, reduce the synthesis tiroksina in the thyroid gland, which has a specific therapeutic effect with its hyperactive. Like other substances antitireoidnym also lowers the main exchange.

     The drug speeds up the withdrawal of thyroid iodine, injures active enzyme systems involved in the oxidation of iodine in iodine, causing braking iodization tireoglobulina and delay in turning diyodtirozina tiroksin. Furthermore, the synthesis tiroksina may depend on the reaction metiltiouratsila free iodine, formed in the thyroid gland of iodine.

     Applied to diffuse toxic goiter (light, moderate and severe forms).

     Assign inside after eating : in the form of light and medium-thyrotoxicosis to 0,005 g 3 - 4 times a day, with severe-to 0.01 g 3 - 4 times a day.

     After remission (after 3 to 6 weeks) daily dose reduces every 5 to 10 days at 0,005 - 0,01 g and gradually picked maintaining minimum dose (1 g 0,005 times a day, every other day or once every 1 3 days) before receiving permanent therapeutic effect.

     When too early termination possible relapse of disease.

     There is the value of combining merkazolila with lithium carbonate.

     Higher doses for adults inside : single 0.01 grams daily 0.04 g.

     Merkazolil usually well in dosage. It should, however, be under the supervision of a doctor once a week to make the study of blood, as in some cases can develop radiation; There may also be nausea, vomiting, liver function violations, zobogenny effect of pharmacological hypothyroidism, skin rashes, pain in joints. In developing side effects reduce the dose or stop further admission of drug.

     Patients who are receiving merkazolil in preparation for the operation may increase bleeding thyroid, therefore, reaching remission or significant improvements in patient merkazolil cancel, appointed iodine preparations; Operations produced after 2 - 3 weeks.

     Contraindicated for pregnant while breastfeeding, as expressed by radiation and granulotsitopenii, key forms goitre (except heavy progressive disease, which temporarily impossible to operations).

     It should not be combined with the admission merkazolila drugs, which can cause hemorrhagic (Amidopyrine and its analogues, sulfanilamidy etc.).

     Product : 0,005 tablets of the city

     Storage : List B. In the dark, dry place.

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