MEROPENEM (Meropenem).

     Synonym : Meron, Meronem.

     The structure and action close to imipenem.

     Compared with last meropenem more resistant to the actions of renal digidropeptidazy. In this regard, can be used (as opposed to imipenem) without inhibitor digidropeptidazy - tsilastatina.

     Meropenem like imipenem, blocks the synthesis of cell walls of microbes.

     It has a wide range of microbicides. It has an impact on most gram and gram, aerobic and anaerobic bacteria. Resistant to? - Laktamaz.

     When applied in a wide range of infections (lower respiratory tract, urinary tract, abdominal, skin, soft tissues, bones and joints, gynecological infections, sepsis, meningitis, endocarditis, etc.), including heavy due polirezistentnymi mikroolrganizmami. Can be used for "empirical" chemotherapy.

     Assign intravenous and intramuscular injection.

     Enter drip intravenously (as Infusion) or bolyusno adults to 0.5 g every 6 hours or 1 g every 8 hours; Children-at the rate of 10-20 mg / kg 3 times a day. The average length of treatment for 10-14 days. In the most severe infection (meningitis) dose for adults can be increased to 6 grams a day (about 120 mg / kg / day); For children weighing more than 50 kg to 40 mg / kg 3 times a day.

     In bolyusnom introduction (for 5 min) by dissolving 0.25 g of the drug in 5 ml isotonic sodium chloride solution, or 5% glucose solution, and Tank (within 15-30 minutes), in 50-250 ml solvent.

     Intramuscularly imposed on 1-1,5 g / day (2-3 admission).

     Solutions are ex tempore.

     In applying the drug for : headache, parestezii, diarrhoeal phenomenon, disruption of the liver, candidiasis, radiation, neutropenia, thrombocytopenia, throm, allergic reactions and other side effects.

     Product : powder for injection solutions in bottles of 0.5 or 1 year

     Storage : List B.

Materials allowed to copy only with the active hyperlink to the handbook of medicines