METAMIZOL sodium (sodium Metamizole).

Chemical name : Sodium salt of [(2,3-dihydro-1, 5-Dimethyl okso-2- fenil-1H- pirazol- 4-mud) metilamino] metansulfonovoy acid (and as monohydrate)

     Description : Black or white with a barely noticeable yellowish sheen crystalline powder, in the presence of moisture quickly degrades. It is soluble in alcohol, easy-water, the aqueous solution pH is 6-7,5.

     The drugs act : anti-drugs operation, analgeziruyuschee, cough. Io is depressing activity reduces education endoperekisey, bradikininov, some PG, free radicals, ingibiruet the peroxide oxidation of lipids. Prevents an extra pain and proprioceptive counters on bundles Gaulle and Burdaha increases excitability talamicheskih points threshold of pain sensitivity, increase heat dissipation. When administered quickly and completely absorbed. In the bowel wall hydrolyses education active metabolite - Metamizole unaltered in the blood is not available (only in / in a small concentrations detected in the plasma). Level linking the active metabolite of proteins is 50-60%. Destroyed in the liver. Excretion passes through the kidneys. Effects develops through 20-40 minutes and reaches its maximum in 2 hours

     Indication : Artralgii, rheumatism, trochaic pain : headache, dental, menstrual, neuralgia, ishialgiya, mialgiya with cramping (kidney, liver, intestinal), a light heart attack, heart attacks, rasslaivayuschey anevrizme rivers, clogging the main vessels, inflammatory processes (pleurisy pneumonia, lumbago, myocarditis), trauma, burns, duct disease, depriving newspapers, tumors, day, pancreatitis, peritonitis, perforation of the oesophagus, pneumothorax, posttransfuzionnyh complications priapism; the fever syndrome in acute infectious, investments and urologic diseases (prostate) biting insects (mosquitoes, bees, dominant, etc.).

     Contraindications : Giperchuvstvitelnost, oppression blood (agranulotsitoz, cytostatic neutropenia or infection), serious violations of liver or kidney function, prostaglandinovaya bronchial asthma, hereditary Hemolytic anemia associated with a deficit glyukozo-6- fosfatdegidrogenazy, pregnancy, breast-feeding (at the time of treatment ceased).

     Side Effects : Granulotsitopeniya, agranulotsitoz, thrombocytopenia, haemorrhage and hypotension, interstitial nephritis, allergic reactions (including Stevens-Johnson syndrome, Layella, bronchospasm, anaphylactic shock).

     Special instructions : The application may metamizola red staining of urine through an metabolite.

     Drug interactions : Effect increase barbiturates, codeine, gistaminovye H_2- blockers, Inderal (slows inactivation). Sarkolizin and merkazolil radiation increases the likelihood of development. Increases Activity oral hypoglycemic drugs antidiabetics (release of proteins related to blood), sedative-alcohol reduces the concentration of cyclosporine in the plasma.

     Overdosing : Symptoms : hypothermia expressed hypotension, rapid heartbeat, dizziness, noise in the ears, nausea, vomiting, weakness, drowsiness, delirium, a violation of consciousness convulsant syndrome; Possible development of acute agranulotsitoza, haemorrhagic syndrome, acute renal and liver failure. Treatment : induction vomiting, stomach chrezzondovoe washed, the appointment of salt softeners, activated carbon and forced diureza, HCl blood symptomatic therapy aimed at maintaining vital functions.

     Precautions : A medical follow-up (high frequency allergic reactions, including fatal, especially in parenteral introduction). Not recommended regular long reception by mielotoksichnosti. Deleted use for the lifting of acute pain in the abdomen (to determine the cause). In appointing patients with acute cardiovascular disorders should be carefully monitored hemodynamics. To use caution in patients with sAD level below 100 mm Hg. Art. With guidance unaccounted for kidney disease (medicine, Glomerulonephritis) and with a long history of alcohol.

     Dosing and Administration : W / m or / in (with the powerful pain), 1-2 ml of 50% or 25% solution 2-3 times a day with a maximum daily dose of 2 g; Introducing children to 0,1-0 , 5 ml. After eating inside or rectally to 250-500 mg 2-3 times a day, maximum single dose of 1 g daily, 3 g. Regular dose for children 2-3 years 50-100 mg, 4-5 years - 100 200 mg, 6-7 years - 200 mg, 8-14 years, 250-300 mg 2-3 times a day.

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