METILDOFA (Methyldopa) *. (-) 3-(3, 4-Dioksifenil) -2 - metilalanin, or a 3-acid-methyl L-Tyrosine.

     Synonyms : Aldomet (H name drug companies "MERCK CO. , INC. , Rahway, N. J., U. S. A.), Dopegit, Aldomet, Aldomin, Alfamet, Dopamet, Dopatec, Hypotonal, Levomet, Medomet, Metildopa, Methyldopum, Modepres, Normopres, Presinol, Presolisin and others.

     Methyldopa an effective antihypertensive funds. With the body he crosses the blood-brain barrier and in the central nervous system metabolised, becoming the first in-metildofamin, in a then-metilnoradrenalin. The latter, like klofelinu, stimulates the central 2-adrenoretseptory, inhibits sympathetic impulsatsiyu, thus reducing blood pressure. Hypotension accompanied by slower heartbeat, decrease emissions and reduce heart of peripheral vascular resistance.

     Metildofu applied as a means of anti-hypertensive in different ways hypertension, especially in stage II A II and B.

     The drug is usually well. Orthostatic hypotension is rare. At the heart function of the preparation of direct action and normally does not have is speed klubochkovoy filtering and reducing blood flow to the kidneys. In connection with the preparation adrenergicheskie of brain often has sedative effect.

     Is metildofu (aldomet) inside in the form of tablets (to 0.25 g). Adults are usually appointed from 0.25 g 2 - 3 times a day. If necessary, increase the dosage to 1 - 1 5-2 grams per day. The maximum daily intake for adults-Z city

     Children need to appoint from 0.01 g (10 mg / kg) per day (2 - 4 admission), then picked dose individually depending on the effect. The maximum daily dose for children 65 mg / kg.

     Often metildofu appoint, in conjunction with saluretikami antigipertenzivnymi and other drugs, the dose can be reduced somewhat metildofy. Combining with saluretikami especially shown in the cases of delays in body fluids and there swells.

     It should be noted that since the end of metildofy anti-hypertensive effect relatively quickly terminated, increased blood pressure is usually within 48 hours.

     A number of patients through one-one, 5 months after receiving the drug develops and anti-hypertensive effect is reduced; In such cases, appropriate to appoint metildofu in conjunction with other tools and antigipertenzivnymi diuretikami (gidrohlortiazidom). When combination therapy slightly lower dose. When combined metildofy (aldometa) in the dose of 0.5 g to 0.05 g (50 mg) gidrohlortiazida drugs can be applied once a day.

     In applying metildofy can develop headache, weakness, diarrhoeal events (nausea, vomiting) may Blush top half of the body, raising body temperature. In rare cases may develop reversible radiation and thrombocytopenia. Sometimes developed haemolytic anaemia. Possible violations of liver function with the development of cholestasis, jaundice.

     Drug treatment should be under the control functions of the liver and blood picture.

     The drug is contraindicated in acute liver diseases (hepatitis, cirrhosis, etc.), with feohromotsitome, pregnancy. Methyldopa enters the mother's milk, and therefore should be carefully weigh the benefits and possible risks of drug use among nursing mothers.

     Methyldopa allocated mainly kidneys. If the kidney function of the preparation should be appointed in small doses. Urine patients receiving metildofu, is standing in the dark (the reaction to the drug and its metabolites).

     In appointing metildofy sick middle-aged and elderly should be careful as possible sharp decline in AD. Assign be from 0.25 grams and only gradually increase the dose.

     When using drugs should take into account its ability to provide sedative effect.

     Product : pills to 0.25 g.

     Storage : List B. In dry, the dark spot.

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