METILPREDNIZOLON (Methylprednisolonum). 6 - a-Metilprednizolon :

     Synonyms : Medrol, Metipred, Urbazon, Bioprednon, Medeson, Medrate, Medrelon, Medrol, Medrone, Meristolone, Mesopren, Metastab, Methypred, Metipred, Metrisone, Moderin, Prednol, Promacortine, Suprametil, Urbason, Wyacort and others.

     Analogous prednisolone. For activity similar to prednisolone, but little has mineralokortikoidnoy (natriyzaderzhivayuschey) activity that provides better portability. He slowly absorbed by intramuscular and has a more lasting effect than hydrocortisone and prednisolone.

     Indications for use are the same as for prednisolone, but metilprednizolon in some cases, more active, more shifts.

     Available in tablets of 0,004 grams (4 mg) and 0,016 g (16 mg). In soluble form (as sodium succinate) in ampoules of 0.02 and 0.04 g (20 and 40 mg) for adults and 0,008 g (8 mg) for children (dry powder to annex capsules with the solvent - sterile water for injection), and capsules manufactured solution of 40 mg in 1 ml.

     In bronchial asthma appointed interior, ranging from 12-40 mg / day; Supporting dose of 4 to 12 mg per day. In chronic polyarthritis appointed from 6 to 20 mg per day. In rheumatoid arthritis starts with 0,8-1 dose, 5 mg / kg, then gradually diminish.

     In severe cases, give muscles or veins (or drip slowly struyno) for adults 20 to 40 mg, for children 8 to 16 mg, then move on to receive the drug inside.

     Solution metilprednizolona if necessary introducing cavity joints (10-40 mg) in the abdominal and chest cavities (up to 100 mg), the conjunctival (up to 20 mg).

     There is evidence of epidural introduction metilprednizolona (80 mg in 10 ml isotonic sodium chloride solution) for the treatment diskogennogo back.

     Large doses metilprednizolona (or prednisolone) used in the treatment of the most severe forms volchanochnogo jade.

     Contraindications to the appointment metilprednizolona and possible complications are the same as in the application of glucocorticosteroids other.

     Method of issuance : pills to 0,004 grams (4 mg) in a package of 30 pieces; In ampoules of 0.02; 0.04; 0,008 grams (20; 40 and 8 mg), sodium succinate metilprednizolona annex vials with the solvent ; preparation <<Solu- Medrol>> (Solu-Medrol), a sodium suktsinatom metilprednizolona, issued in vials.

     Prolonged drug "Depomedrol" (Depot-Medrol) is a 40% suspension metilprednizolona acetate; Issued on 1 mg and 2 ml. Intramuscularly applied for 0.04 - 0.12 g (1-3 ml) every 1 1 - 4 weeks. In the joint cavity enter depending on the joints of 0,004 to 0,08 g (4-80 mg) every 1 1-5 weeks. In some cases, a single injection.

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