METILURATSIL (Methyluracilum). 2 Diokso-6- 4-methyl-1, 2, 3, 4-tetrahydrocannabinol Pyrimidine.

     Synonym : Metatsil.

     The white crystalline powder and odourless.

     Little is soluble in water (up to 0.9% at a temperature of + 20 'S) and alcohol. Aqueous solutions (pH 7, 0) are sterilized at a temperature of 100 + 'C for 30 min.

     On metiluratsil chemical structure of the derivatives pirimidina. According to experimental data, the number of drugs in this group (metiluratsil, pentoksil etc.) has antikatabolicheskoy and anabolic activity. These drugs speed up processes cell regeneration; Faster healing, and stimulate cell gumoralnye protective factors. They also have anti-inflammatory effect. A characteristic feature of this series is to foster erythrocytes and especially leykopoeza, for which they usually refer to the group of stimulants leykopoeza.

     As stimulator leykopoeza metiluratsil appointed in agranulotsitarnoy flu, alimentarno- aleykii toxicity, chronic benzene poisoning, radiation from the chemotherapy of malignant neoplasms, with X-ray and radiotherapy, and other states, accompanied by radiation.

     Bear in mind that metiluratsil as other stimulants leykopoeza advisable to use in milder forms of radiation. In defeat moderate use of stimulants, blood shown only in the case of resumption of the impaired blood cell regeneration; With heavy losses haematopoietic system metiluratsil not apply.

     Assign also weak healing wounds, burns, broken bones.

     There are performance metiluratsila ulcers in the stomach and duodenal ulcers and chronic gastritis. I believe that the therapeutic effects associated with normalization nukleinovogo exchange mucous lining. Applied also hepatitis, pancreatitis.

     Is metiluratsil inside during or after eating. Adults are 0.5 to 4 grams per day (if necessary to 6 times a day); Children aged 3 to 8 years - 0.25 grams over 8 years - 0.25 - 0.5 g 3 every day.

     The course of treatment in cases of the gastrointestinal tract continues normally 30 to 40 days, in other cases it might be shorter.

     When local trauma (defeat skin proktitah, sigmoiditah, etc.) caused by radiation therapy, appointed interior and local.

     Locally, with wounds, burns, trophic ulcer 10% metiluratsilovuyu apply ointment. To treat rektitov, sigmoiditov, ulcer colitis using candles containing metiluratsil (1 - 4 candles in adult day). There may also apply mikroklizmy (0.2 - 0.4 g metiluratsila to krahmalnom mark of 20-25 ml). Local irritants in the tissue metiluratsil not help.

     There are indications that metiluratsil of masi (5%) and the cream has fotozaschitnoe effect in patients fotodermatozami.

     Metiluratsil usually well; When a candle in the rectum, there is sometimes a short light burning; When administered possible allergic skin reaction (urtikarnaya rash), sometimes headache, dizziness.

     The drug is contraindicated in acute and chronic forms of leukemia leykemicheskih (especially mieloidnyh), chlamydia, malignant bone marrow disease.

     Method of issuance : powder; Tablets of 0.5 grams in a package of 50 pieces, candles with metiluratsilom to 0.5 g (Suppositoria cum Methyluracilio 0.5) in a package of 10 candles; Metiluratsilovaya 10% ointment (Unguentum Methyluracili 10%) aluminium tubes for 1925

     Metiluratsil member of the vegetable "Levomekol and Levosin."

     Storage : List B. In a dry, cool place.

     Sponge "Meturakol" (S-ro ngia "thuracolum Me").

     Melkoporistye plate of dry white collagen or collagen masses containing 1 g to 0.05 g metiluratsila.

     Applied as local funds for the treatment of trophic ulcers, bedsores, the long-term healing the wounds superficial burns.

     Placed on the wound surface (after removal of necrotic masses and processing antiseptic); Dressings do one every 2 to 3 days. During this period sponge usually resolved.

     When dry sponges and shrinking possible pain; In these cases sponge moistened with 0.25% solution of novocaine or antiseptic solution (furatsilina etc.). If there allergic reactions, sponge removed.

     Product : plate 90 x 90 mm (+ 10 mm), 10 mm thick in hermetically ukuporennyh polyethylene bags 10 pieces in the package.

     Storage : dry, the dark place at room temperature.

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