METOKLOPRAMID (Metoclopramidum). 4-Amino hlor-N- (2-ethoxylate ztil) -2 - metoksibenzamida hydrochloride.

     Synonyms : Klometol, Reglan, Tserukal, Bimaral, Cerucal, Clopan, Comportan, Emetisan, Gastrobids, Imperal, Klometol, Legir, Maxeran, Maxolon, Metoclol, Metoclopramide, Metoklopramid, Moriperan, Nausifar, Paspertin, Peraprin, Perinorm, Plastil, Pramin, Primperan, Primperil, Regastrol, Reglan, Reliverin, Rimetin, Terperan, Viscal et al.

     On chemical structure similar to sulpiridu (see) and dimetpramidu (see).

     Metoclopramide is specific blokatorom dofamine (D 2) receptors and serotonin (5-NTz) receptors.

     The drug has protivorvotnoe act soothes ikotu and also has a controlling influence on the function of the gastrointestinal tract. Tone and the motor activity of the digestive system worsens. Secretion stomach does not change. There are indications that the drug helps heal stomach ulcers and gastrointestinal cancers.

     Metoclopramide used as a means protivorvotnogo with nausea, vomiting associated with the anaesthetic, radiation therapy, side effects of drugs (drugs lapidary, drugs, antibiotics, etc.), diet and other violations

     At vomiting vestibular genesis, it is not operating.

     In practice Gastroenterological drug is used in the treatment of gastric ulcers and duodenal ulcer, gastritis, diskinezy abdominal, postoperative bowel appearances with flatulence and other diseases.

     The beneficial effects associated with increased tone stomach and intestines, stomach emptying faster and concierge, reducing giperatsidnogo staza.

     There are performance metiklopramida to treat neuralgia (repeated vomiting, nausea) from heavy heart patients (myocardial infarction, heart failure), and vomiting pregnant.

     The drug is also used as a means of facilitating and improving screening of gastric diseases and small bowel.

     There is the high efficiency of metoclopramide with migraines and the successful use of the drug with Tourette's syndrome (sub-culture and vocalization children).

     Applied metoclopramide inward, and in severe cases dropped.

     Inside are usually adults and 10 mg (one tablet) 3 times a day (before meals). Intramuscularly (or intravenously) to impose one ampoule (2 mL of 10 mg drug) 1 to 3 times a day. Children designate smaller doses in accordance with the age (for children aged 6 years and 1 / 2 - 3 1 pill twice a day).

     Pills proglatyvayut not liquid, squeezed a small amount of water.

     For x-rays are adults and 1 - 2 capsules (10-20 mg) given intravenously or inside (for 5-15 minutes before the start of the study), 15 to 30 mg.

     The drug is usually well. In rare cases may extrapiramidale disorder characterized parkinsonizma (giperkineto- distonicheskie phenomenon). In the framework of these side effects has apparently antagonistic role of metoclopramide dofamine receptors in the brain. To address these phenomena are parenteral caffeine.

     Children under the age of 14 years should be about the possible side effects appoint drug with caution.

     Before the drug can also disturbances, noise in the ears, dry mouth. To reduce these phenomena drug designate sometimes after eating.

     When using drugs by injection could disrupt the ability to drive vehicles and to the work requiring special focus.

     Method of issuance : 10 mg tablets in a package of 50 pieces; In ampoules of 2 ml (10 mg in the ampoule) in a package of 10 vials.

     Storage : in the dark spot.

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