NALORFIN (Nalorphini hydrochhloridum).

     N-allilnormorfina hydrochloride.

     Synonyms : Antorfin, Anarcon, Lethidron, Nalorphine hydrochloride, Nalline, Norfin and others.

     White or white to slightly yellowish sheen crystalline powder (for air and light to dark). The easily soluble in water, it is difficult to alcohol.

     On nalorfin chemical structure similar to morphine and is only a allyl balance instead Hartree piperidinovogo nitrogen atom in the ring. This relatively small modification of morphine resulted in a compound that has not only agonist, but also an antagonist to the opiate receptors.

     Nalorfin agonistic effect of providing analgetichesky effect, but to a much lesser degree than morphine. As it weakens antagonist respiratory depression, lowering blood pressure. Measuring heart and other changes in the organism, which may be caused by morphine and its analogues nalorfinom removed. Nalorfin also reduces the analgesic effect of morphine and other drugs analgetikov and their impact on the tone of smooth muscles.

     Initially, before <<clean>> morphine-antagonist naloxone, nalorfin used as an antidote to heavy breathing oppression and other abuses of the body, caused by acute poisoning with an overdose of morphine, promedola, exhibited or other drugs analgetikov an elevated sensitivity to them.

     Currently nalorfin for this purpose was little used; Naloxone was replaced.

     Its nalorfinu moderate analgesic effect may not be used for practical purposes, as it can cause mental institution, alarming state hallucinations.

     If naloxone as antidote against its injected, subcutaneously or intramuscularly. Better intravenous. Adults appoint 0,005 - 0,01 g (1 - 2 ml of 0.5% solution). With insufficient effects injections repeat at intervals of 10 to 15 minutes. The total dose should not exceed 0.04 grams (8 ml of 0.5% solution).

     A newborn baby introducing non-0.00025 0.0001 g (0,2-0,5% 0.05 ml of solution), you can repeat injections at intervals 1 - 2 minutes. The total dose should be no more than 0.0008 g (0.8 mg).

     Introduction nalorfina normally not accompanied by side effects. Large doses can cause nausea, cramps, drowsiness, headaches, mental agitation.

     A drug application (morfinistov) nalorfina might attack phenomena characteristic symptoms.

     To treat chronic morphinism nalorfin not used.

     When oppression and violations of respiratory diseases caused by barbiturates, tsiklopropanom, ethyl ether, nalorfin antagonistic not help. In these cases, Bemegride (see).

     Product : 0.5% solution in ampoules and 1 ml (for adults) and 0.05% solution in ampoules of 0.5 ml (for infants).

     Storage : List A. Banks orange glass; Capsules-in the dark spot.

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