SODIUM PARA- AMINOSALITSILAT (Natrii para-aminosalicylas). 4-Amino-2- acid, sodium benzoate, sodium salt, or para-aminosalitsilovoy acid.

     Synonyms : PASK- sodium, Aminacyl, Aminopar, Aminosalyl, Aminox, Apacil, Bactylan, Eupasal, Natrium para-aminosalicylicum, Pamisyl, Paramisan, Para-Pas, Parasal, Pasalicylum solubile, Propasa, Tebaminal, Teebacin, Tubopas, Wofapas and others.

     White or white with a slight amber or slightly rosy shade melkokristallichesky powder. The easily soluble in water, it is difficult to alcohol. Para-aminosalicylic acid and its sodium salt (abbreviated PASK) have bakteriostaticheskoy activity against M. tuberculosis and tuberculosis are the main drugs.

     When ingestion, PASK well absorbed and enters the blood serum and tissue of internal organs.

     On tuberkulostaticheshoy activity PASK losing isoniazid and streptomycin, and its combination with other, more active, anti-TB drugs (isoniazid or other drugs izonikotinovoy acid hydrazide, cycloserine, kanamycin, etc.). Combination therapy slows the development of drug resistance and enhances the effect of the drugs.

     PASK in combination with other drugs effective in various forms and localization of tuberculosis.

     Assign PASK inside as a powder, tablet (Bean) or granules adults and 9 to 12 grams a day (March 3 - 4 g per day), children under 0.2 g / kg / day for 3 to 4 admission (daily dose of not more than 10 grams). Is in 1 / 2 to 1 hour after eating, ?high milk, alkaline mineral water, 0.5 to 2% solution of sodium gidrokarbonata.

     Depleted adult patients (weighing less than 50 kg), as well as in poor endurance drug dose given six grams a day.

     In outpatient facilities may be nominated in the daily dose of 1 reception, but bad Portability daily dose divided into 2 _ 3 admission.

     Sodium aminosalitsilat parameters for admission into drug use in the following forms : a) powder; B) tablets (white or white with donations or yellowish sheen); C) tablets dissolved in the gut (orange and red); G) tablets - coated (Lilac light color or light shade Lilac with donations); e) granules (from light yellow to greenish-yellow), containing 1 part of sodium para-aminosalitsilata and 2 of sugar; e) injection. The grains are transported better than the net PASK. One teaspoonful holds 6 grams of granules, or 2 g of sodium para-aminosalitsilata and 4 grams of sugar. Taking 1 or 2 tea spoon three times a day, the patient gets 6 or 12 grams of sodium para-aminosalitsilata.

     In applying PASK could experience side effects. The most frequently gastrointestinal disorders : deterioration (or loss) of appetite, nausea, vomiting, abdominal pain, diarrhea or constipation. These phenomena are usually reduced at lower doses or short break in treatment, they are less expressive, with the right (even three) diet, and sometimes in the employment drug pellets. Better than conventional tablets, pills carried sodium para-aminosilitsilata, soluble in the gut (Tabulettae Natrii para-aminosalycilatis enterosolubies 0.5).

     When using sodium para-aminosalitsilata may also be allergic reactions : dermatitis type urticaria or purpury, enantemy, feverish reaction, asthma phenomenon, pain in joints, eosinophilia, etc. In some cases, can increase pain and liver.

     Depending on the nature and gravity of allergic phenomena reception drug should temporarily or completely terminated; Designate protivogistaminnye drugs, calcium chloride, ascorbic acid, as long allergies - corticosteroid hormones.

     In the treatment process to be systematically studied urine and blood test and functional state of the liver.

     In high doses PASK has antitireoidnoe effect, in long-term use may occur, zobogenny effect. This feature PASK remember if patients have hypothyreosis gland.

     Contraindications : expressed kidney disease (nephritis), liver (hepatitis, cirrhosis), amiloidoz, ulcerative disease, miksedema, cardiac decompensation.

     Prudence followed observe in patients with moderately expressed pathology gastrointestinal tract.

     For intravenous injection using sodium solution parameters aminosalitsilata 3% for injection (Solutio Natrii para-aminosalicylatis pro injectionibus 3%), the aqueous solution of sodium salt parameters aminosalitsilovoy acid containing preservative.

     Antiseptic transparent liquid colourless and odourless; The solution pH 6, 8, 8, 1; When sterile + 100 C for 30 min.

     When intravenously to obtain high concentrations of sodium aminosalitsilata parameters in the blood, hence the chemotherapeutic effect of the increase.

     If necessary, designate a solution of sodium para-aminosalitsilata with isoniazid solution.

     Mortar used in patients with progressive forms of active tuberculosis, mainly fibrozno- cavernous chronic pulmonary tuberculosis, previously treated unsuccessfully with anti-tuberculosis drugs.

     A solution of sodium para-aminosalitsilata give venous drip. Started with 30 drops per minute and after 15 minutes, in the absence of local and systemic reactions increased to 40-60 minutes. The first infusion impose no more than 250 ml, in the absence of side effects for 500 ml.

     Oh do 5 to 6 times a week or every other day (alternating hosting PASK inside). The course of treatment typically lasts 1 to 2 months, rarely more.

     Solution 3% sodium para-aminosilitsilata injected under the close supervision of a physician. It should be borne in mind the possibility of bruises and flebitov; To prevent these complications have taken thin needles alternate veins for a solution. Sometimes there feeling heat, increased body temperature, diarrhoeal phenomenon toksikoallergicheskie reaction. If the technology infusion (rapid, low clearance system, through which fits solution of the drug residue from the previous injection) is possible shocks; In these cases, stop pouring, impose solution of morphine and cordial means.

     Intravenous a solution contraindicated hepatitis, nefrozonefritah, miksedeme and cardiovascular II and III stage, heavy atherosclerosis, throm, violations of blood coagulability.

     Product : 3% solution in vials containing 250 or 500 ml.

     Storage : powders and granules in a well-ukuporennyh banks orange glass; Pill-well ukuporennoy packaging; All dosage forms in the dark spot.

     Solutions lost translucent or changed colour to the use of unsuitable.

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