NIALAMID (Nialamidum). 1-[2 - (Benzilkarbamoil) - ethyl] -2 - izonikotinoilgidrazid.

     Synonyms nialamida : Niamid, Novazid, Nuredal, Espril, Niamid, Niaquitil, Nuredal, Nyazin, Psicodisten and others.

     White or white with a yellowish sheen weak melkokristallichesky powder. Little is soluble in water, it is difficult to alcohol.

     Nialamide antidepressantov- is one of the first generation of MAO inhibitors.

     Chemically Nialamide close iproniazidu : both are derivative izonikotinovoy acid hydrazide (Iproniazid excluded from the range of medicines)

     Nialamide is indiscriminate and irreversible MAO ingibitirom, but it is less toxic than iproniazid. Despite the potential side effects when used, it has maintained its importance as a drug. According to reports, MAO inhibitors are often more effective than other antidepressants (drugs), and <atypical> depression.

     Nialamide applied in psychiatry at the depressed state of the various forms of diseases combined with the sluggish, inhibition, lack of initiative, including involyutsionnyh, neurotic and tsiklotimicheskih depression.

     Assign inside (after eating) in the form of tablets, from 0,05-0,075 g (50-75 mg) a day, preferably in 2 admission (morning and afternoon), in order to avoid violations of sleep a night; If necessary to increase the dosage gradually 25-50 mg / day and 200-350 mg per day <in resistant cases, sometimes up to 800 mg).

     The therapeutic effect in treating nialamidom is usually 7 to 14 days. Duration of treatment individually (1 to 6 months). After the therapeutic effect gradually reduce the dose of the drug.

     In neurological practice Nialamide sometimes designated for the treatment chamber troynichnogo nerve and other pain syndromes.

     There are indications that Nialamide (0,025 g 2 - 3 times a day) reduces the frequency and intensity of strokes.

     Published performance nialamida (nuredala) in the treatment of chronic alcoholism. The use of the drug (50 to 200 mg per day) increase in overall health and cognitive function (cognitive).

     Nialamide relatively well tolerated. In some cases, there diarrhoeal phenomenon, lowering systolic pressure, anxiety, insomnia, headache, dry mouth, delay chairs and other side effects.

     The drug is contraindicated in patients violations as liver and kidney, cardiac decompensation in activities violating cerebral circulation (in relation to the emergence Orthostatic hypotension).

     There should be appointed Nialamide patients with azhitirovannymi state.

     In appointing nialamida must, however, take into account the possibility of side effects associated with the inhibition of MAO. Thus, after applying nialamida (while they) can appoint hydrochloride and other antidepressant drugs, as well as MAO inhibitors; A 2 - 3-week break.

     To avoid development <> (cheese tiraminovogo) syndrome during treatment nialamidom be deleted from the diet foods containing tiramin and other sosudosuzhivayuschie monoaminy (Beta, etc.), including cheese, milk, coffee, beer, wine, smoked meats.

     There should be appointed Nialamide while rezerpinom (and raunatinom), as well as possibly drastic action.

     In order to sleep at night not to take Nialamide during the evening hours.

     It should be borne in mind that, like other MAO inhibitors, Nialamide potentsiruet of barbiturates, analgetikov, local anesthetics, and other hypotensive drugs, it should be a combination of (if necessary) with caution.

     Product : pills (pills) to 0,025 g (25 mg).

     Storage : List B. In a dry, cool, the dark spot.

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