NIKOTINOIL- GAMMA- AMINOMASLYANAYA ACID (Nicotinoyl-gamma-aminobutyric acid)

     Description : Molecular weight 230.20. The white crystalline powder and odourless. Gigroskopichen, readily soluble in water. An aqueous solution-transparent colourless liquid.

     Pharmacology : The drugs act-nootropic, improves cerebral blood circulation.

It improves blood circulation and functional state of the brain. Decreases vascular resistance and increases the velocity of blood vessels in the brain, improves, including in retinal, ingibiruet aggregation of platelets. Influence of central processes GAMKergicheskie vazomotornoy regulation. It stimulates the metabolism in nervous tissue has antigipoksicheskoy activity. Improves thinking, attention, memory, speech, the ability to learn, increases resistance to the central nervous system adverse factors restores mental and physical fitness to overload. Normalizes sleep, reduces anxiety, tension, fear (provided trankviliziruyuschy effect without miorelaksatsii, weakness, drowsiness). It has psychoactive effect, reduces the dampening effect of ethanol on the central nervous system. Has lipid and antioxidant effects, injures MAO activity in the brain. The patient's condition improves violating speech and motor disorders.

Rapidly absorbed from the digestive tract, easily permeates through the GEB, bioavailability of 50-80%. Distributed in the brain, kidney, muscle and adipose tissue of long-term retention in the tissues of the body. Virtually no metabolised, with urine output unchanged, T1 / 2 - 0.51 h. Malotoksichen.

      Application : Acute ischemic cerebral circulation of light and medium gravity, and recovery subacute ischemic stroke, cerebrovascular insufficiency, distsirkulyatornaya encephalopathy, dystonia vascular dystonia, astenichesky syndrome, depression, psychosis senilny, state after craniocerebral injury and CNS; Migraines; state accompanied by anxiety, fear, increased irritability, emotional lability (in the adjuvant therapy); mild acute alcohol intoxication (in the adjuvant therapy), chronic alcoholism (decrease Pichinde, astenonevroticheskih, postpsihoticheskih, predretsidivnyh state), alcoholic encephalopathy; improve physical endurance and mental loads (intense and extreme activity, the restoration of the physical fitness of athletes). Mental urination (organic, functional).

In ophthalmology : primary otkrytougolnaya offset pressure from glaucoma, retinal disease and visual nerve vascular genesis (of adjuvant therapy) inwards retrobulbarno in / m.

     Contraindications : Giperchuvstvitelnost, kidney disease (acute, chronic).

     Restrictions on the use : It is not recommended to severe acute violations of cerebral circulation.

     Side effects : Nausea, headache, dizziness, irritability, arousal, anxiety, allergic reaction (rash, itching of the skin); Tidal blood to a person Blush person parestezii (with the rapid on / in the introduction).

     Networking : Ukorachivaet of barbiturates.

     Dosing and Administration : inside, regardless of the meal.

Cerebrovascular diseases : 0,02-0,05 g 2-3 times a day, daily intake 0,06-0,15 g treatment 1-2 month refresher course recommended by 5-6 months.

Astenicheskoe condition depression later age, the restoration work and at elevated pressures : 0,04-0,2 g / day for 2-3 reception during 1-1,5 months (with depression to 3 months), 2-week-athletes Training period.

Migraine : Prevention attack-0.05 g 3 times daily; Mild attack-0.1 grams a time.

Alcoholism during abstinence : 0,1-0,15 g / day for 6-7 days, with a persistent violations outside of abstinence-0,04-0,06 g / day for 4-5 weeks.

Primary otkrytougolnaya glaucoma : 0.05 g to 3 times a day to 1 month. In ophthalmic practice in the following / m (12 days) or a parabulbarnogo depending on the state of 0,02-0,05 g 3 times a day to 1 month.

Mental urination : children : a functional disorder of urination, 3-10 years, 0.04 g / day over 10 years, 0.06 g / day in the reception 2-3; Myelodysplasia with children under 10 years of 0.06 g / day, 11 - 15 0.1 g / day for 3 admission; adult - 0.15 g / day in 3 admission rate of 1 month.

Parenteral : w / struyno (slowly) drip (the contents of capsules prior to throw in 200 ml isotonic sodium chloride solution); In / m.

Acute and chronic violation of cerebral circulation : v / or / m 0,1-0,2 g (2 ml 5-10% solution) 1-2 times daily in the daily dose of 0,2-0,4 g scheme : in the morning / to drip evening / m; or 10 days / w, then / m course 15-30 days.

Astenicheskoe condition : in / m 0,2-0,4 g / day (2-4 ml of 10% solution), 1 month.

Alcoholism : in / m 0,1-0,3 g / day to 1 month. Acute uncomplicated acute ethanol intoxication : / w in saturating dose of 5 mg / kg dose supporting - 1.56 mg / kg / h of 2.5 l Estimated solution during the 4-hour morning and evening.

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