NIMODIPIN (Nimodipine) *. 2, 6-Dimetil-4- (3-nitrophenyl) -1, 4-dihydro-3, 5-piridindikarbonovoy acid metoksietil-1- ovyy- isopropyl diefir.

     Synonyms : Nimotop, Nimotop.

     Nimodipine derivative-1, 4-digidropiridina close to a structure nifedipinu (see).

     Refers to a group of antagonists of calcium ions (see) and has the characteristic of these drugs. However, a feature nimodipina is its predominant influence on blood brain, the ability to reduce resistance resistant receptacles (arteriol) brain, improve cerebral blood circulation, reduce the hypoxic event.

     Nimodipine found use as a prophylactic and therapeutic tool in violation of ischaemic cerebral circulation.

     As a therapeutic tool Nimodipine appointed immediately after an acute ischemic (subarhnoidalnoy haemorrhage), and continue treatment for 5 to 14 days. In the first 2 h adults injected (in the form of slow Infusion) to 0,001 grams (1 mg) nimodipina (5 ml of 0.02% solution) 2 times per hour. After 2 h to increase the dose of 2 mg (10 mL) 1 hour (about 30 µ g / kg per hour), hemodynamic monitoring, in order to avoid too abrupt AD. For a (preferably by applying pump) solution to throw in isotonic sodium chloride solution, or 5% glucose solution.

     Oseltamivir appointed interior in the form of tablets (30 mg) every 4 h, 2 tablets (360 mg total per day). Is 4-day haemorrhage within 21 days.

     When intravenously can develop hypotension; When administered as possible headache, nausea and other diarrhoeal phenomenon.

     Caution must be exercised with brain swelling and severe vnutricherepnogo increasing pressure, as well as the violation of kidney function.

     Patients weighing less than 70 kg and labile AD, the preparation should be introduced, starting with small doses (0.5 mg / h).

     It should appoint a drug inside his Infusion. Not recommended for use in pregnancy.

     Method of production : tablets of 0.03 g (30 mg) in a package of 20; 50 or 100 pieces; 0.02% solution in bottles or polyethylene (polyvinylchloride not avoid interaction) package of 50 ml (total 10 mg) for infusions .

     Storage : List B. In a cool place.

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