NITROZOMETILMOCHEVINA (Nitrosomethylurea).

     N-Nitrozo-N- metilmochevina.

     Kremovato- white crystalline powder (or porous mass easily raspadayuschayasya in powder). Moderately rastvorima water. Gigroskopichna. Aqueous solutions nestoyki : stored without degradation in the 20 - 30 min 1% solution of pH 4, 0, 5, 0.

     The drug is cytotoxic alkiliruyuschim funds; Have antitumor activity in a number of malignant tumors. Like other alkiliruyuschie funds can cause in doses close to therapeutic, reversible oppression blood-radiation and thrombocytopenia.

     Applied with chlamydia, cancer of lung (mainly melkokletochnom), melanoma, malignant lymphoma.

     Immediately before the introduction, the contents of a bottle (100 mg drug) dissolve in 5 to 10 ml of sterile water for injection. Enter intravenously for 6-to 10 mg / kg (300-600 mg), 1 in every 3 days. Time course of about one month (August 10-injection). Repeated courses at intervals of 3 to 4 weeks.

     In combination chemotherapy nitrozometilmochevinu give the same doses at intervals determined by the scheme of treatment. Nitrozometilmochevinoy course of treatment in combination with other drugs is 2 - 3 weeks, a break between courses - 2 - 3 weeks. We recommend a minimum of 2 courses.

     When used in conjunction with chlamydia vincristine (rozevinom) or vinblastinom, prokarbazinom, prednisolone and other drugs, in light of cancer in combination with tsiklofosfanom with melanoma, in combination with daktinomitsinom and vincristine or prospidinom and vincristine. There may be other schemes.

     The immediate response to the introduction of toxic nitrozometilmocheviny, most of the patients : nausea, vomiting, diarrhea, occasionally occur in 20 to 40 min after injection. Nausea and vomiting can sometimes staying for several hours, weaker expressed in the preliminary introduction neyrolepticheskih and antiemetics. By the end of treatment may increase anorexia.

     Treatment is carried out under the supervision of regular blood because there might be some radiation and thrombocytopenia. Oppression gemopoeza normal by the end of treatment with total doses of the drug more than 2 g. The oppression blood (leukocyte number less than 3, 5 x 10 9 / L, platelets less than 120 x 10 9 / L) treatment to be interrupted.

     With the introduction of multiple drug in the same vein can induratsiya its walls, can develop flebit, pigmentation of skin and vein during their obliteration.

     Nitrozometilmochevinu should impose strict intravenously : if swallowed drug under the skin necrosis is possible. It should guard against falling solution to the skin, as may be transient skin pigmentation.

     The drug is not suitable for radiation expressed (leukocyte number less than 3, 5 x 10 9 / L), thrombocytopenia (less than 120 x 10 9 / L), in violation of the functions of the liver and kidneys, with a development of cachexia and the terminal stages of the disease.

     Product : to 0.1 g in bottles with a capacity of 20 ml.

     Storage : List A. In the dark place at a temperature of not more than + 5 C.

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