NORFLOKSATSIN (Norfloxacin).

     1-Etil-6- fluorine-1, 4-digidro-4- okso-7- (1-piperazinil) -3 - hinolinkarbonovaya acid.

     Synonyms : Ankvin, Baktinor, Girablok, Kvinoloks, Lockson, Negafloks, Nolitsin, Norbaktin, Norilet, Normaks, Noroksin, Norfloks, Renor, Sofazin, Spektrama, Chibroksin, Yutibid, Anquin, Baccidal, Bactinor, Barazan, Buccidal, Chibroxin, Espeden, Floxacin, Fulgram, Girabloc, Lexinor, Loxon, Negaflox, Nolicin, Nolion, Norbactin, Norfaxin, Norilet, Normax, Norocin, Noroxin, Primoxin, Renor, Sofazin, Spectrama, Uroctal, Utibid, Zoroxin and others.

     Is on the chemical structure of pefloksatsina lack of methyl groups in piperazinilnom kernel.

     Active against most gram and some gram (staphylococci) bacteria. No impact on anaeroby.

     Absorbed quickly, but not entirely (20-40% dose), C max of 60-90 min, T? 2,5-4,5-h; well into the organs and tissues; being low in the liver biotransformation, urine output with mostly unchanged.

     Applied with urinary tract infections, intestinal infections (shigellosis, salmonellosis), eye infections, with otites, prostatitis and gonorrhea.

     Assign the interior and local.

     Inside (1 hour before or 2 hours after meals) is usually applied to 0,2-0,4 g 2-3 times a day over 7-10 days (with chronic recurrent urinary tract infections to 12 weeks); In acute gonokokkovom Urethritis, pharyngitis, proktite, tservitsite - 0.8 g once.

     Locally appoint 1-2 stung eye drops every two hours or four times a day for four drops into each ear 3-4 times a day.

     Can cause side effects from the digestive tract (neuralgia), the urinary tract (Dysuria), central nervous system (insomnia, hallucinations), the cardiovascular system (tachycardia, arrhythmia, arterial hypotension), as well as goiter, candidiasis, radiation, skin allergic reactions.

     The drug is contraindicated in severe renal failure, pregnancy, breast-feeding and age 15.

     Method of issuance : pills to 0.2; 0.4 and 0.8 g (N. 10, 20); 0.3% solution (eye and ear drops) in flakonah- looks to 5 ml (Normaks).

     Storage : List B.

Materials allowed to copy only with the active hyperlink to the handbook of medicines